Prevention of Work-related Asthma: Study Search

Prevention LevelPrimary
Study Year1984
Molecular Weight of AgentHMW
Agent CategoryBiological enzyme
Specific AgentBacillus subtilis derived detergent enzyme
Occupation Detergent industry workers (Includes cohort reported by Kominsky, 1981, CDC, 1981)
Outcome/DiagnosisEnzyme sensitization
Activity Intervention Encapsulation of enzyme (1978)
Participation Rate13 of 14 eligible exposed subjects (Participation rate: 93%) Limitation: no report of participation rates for previously exposed and nonexposed workers
Intervention EffectivenessArea concentrations of enzyme dust did not exceed the American College of Governmntal Industrial Hygienists's (ACGIH) threshhold limit value. Enyme-specific sensitization was detected in 3 of 12 currently exposed workers. Positive results for IgG were obtained in 4 of 12 exposed workers and 1 of 2 previously exposed workers, but in none of nonexposed workers (n=9). Personal breathing sampling indicates that these workers had high-dust exposure levels, exceeding industry guidelines.
Page last reviewed: February 20, 2020