Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
AuthorGrammer
Study Year1996
CountryUSA
Molecular Weight of AgentLMW
Agent CategoryAnhydrides
Specific Agenthexahydrophthalic anhydride (HHPA)
Occupation Workers who manufacture resin requiring use of HHPA (Included cohort reported by Grammer, 1995)
Outcome/DiagnosisOccupational asthma, allergic rhinitis, occupational asthma-rhinitis, hemorrhagic rhinitis
Activity Intervention Medical surveillance, removal from exposure (> 1 year) Medical surveillance consisted of symtpom questionnaire, physical examination, spirometry, chest film, and immunological assays at diagnosis and at follow-up.
Participation RateStudy population consisted of 28 employees identified over a 4-year surveillance period
Intervention EffectivenessOf 28 subjects, symptoms and spirometry normalized in all except except one who had mild asthma. Statistically significant declines in IgE and IgG were also observed at follow-up. Limitation: no comparison group.
Page last reviewed: February 20, 2020