Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
Study Year1992
Molecular Weight of AgentLMW
Agent CategoryAnhydrides
Specific AgentMethyltetrahydrophthalic anhydride (MTHPA)
Occupation Plant workers producing various plastic products exposed to epoxy resin (Includes cohort reported by Welinder, 1990)
Outcome/DiagnosisSensitization and symptoms
Activity Intervention Reduction in exposure (exhaust ventilation), Removal from exposure (median: 2.7 years)
Participation Rate41 of 55 eligible subjects (Participation rate: 75%)
Intervention EffectivenessNo statistically significant decreases were found for atopy, symptoms, and bronchial reactivity. Of the 41 subjects, 5 sensitized subjects were removed from exposure, with none having complaints of symptoms, and all showing lower bronchial reactivity (p=0.02). Of the 41 subjects, 7 sensitized subjects continued to work in the reduced-exposure environment. One of the 7 reported less symptoms with less bronchial reactivity.
Page last reviewed: February 20, 2020