Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
AuthorVenables
Study Year1987
CountryUK
Molecular Weight of AgentLMW
Agent CategoryAnhydrides
Specific AgentTetrachlorophthalic anhydride (TCPA)
Occupation Process workers using TCPA (Includes cohort reported by Howe, 1983)
Outcome/DiagnosisOccupational asthma
Activity Intervention Removal from exposure (4 years)
Participation Rate6 of 7 eligible subjects (Participation rate: 86%)
Intervention EffectivenessOne out of 7 subjects died one year after removal. Five of 7 subjects continued with mild bronchial hyperresponsiveness at follow-up. Specific IgE fell exponentially by a half-life of 1-year, but was still detectable at follow-up. Limitation: no comparison group.
Page last reviewed: February 20, 2020