Prevention of Work-related Asthma: Study Search

Prevention LevelPrimary
Study Year2000
Molecular Weight of AgentHMW
Agent CategoryBiological enzyme
Specific AgentBacillus subtilis derived detergent enzymes (lipase, a-amylase, cellulase)
Occupation Detergent industry workers
Outcome/DiagnosisEnzyme sensitization
Activity Intervention Encapsulation of enzyme, dust control (local exhaust ventilation), use of respiratory equipment (1980's)
Participation Rate76 of 80 eligible subjects (Participation rate: 95%)
Intervention EffectivenessNine of 40 exposed subjects were sensitized (22%). This is in comparison to the prevelances reported in the detergent industry in the early 1970's that ranged from 5% to 40%. None of the non-exposed workers (n=36) were sensitized. Certain areas of production line had concentrations of protease above ACGIH-TLV.
Page last reviewed: February 20, 2020