Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
Study Year2002
Molecular Weight of AgentLMW
Agent CategoryDiisocyanates
Specific AgentToluene diisocyanate (TDI), mold-release overspray
Occupation TDI-production plant workers (Includes cohort reported by Ott, 2000)
Outcome/DiagnosisOccupational asthma
Activity Intervention Improvement in local exhaust ventilation, engineering controls, medical surveillance Medical surveillance consisted of respiratory questionnaire, spirometry, and physical examination at preplacement and at 1, 3, 6 months afterward. Surveillance is biannual after 6 months until 2 years, when it becomes annual.
Participation Rate4 of 4 eligible subjects (Participation rate: 100%)
Intervention EffectivenessAfter reduction in exposure to mold release overspray following environmental hygiene improvement, subjects identified with OA (n=4) via TDI-medical surveillance resumed former work with no recurrence of respiratory symptoms. Limitation: no comparison group.
Page last reviewed: February 20, 2020