Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
Study Year1992
Molecular Weight of AgentLMW
Agent CategoryDiisocyanates
Specific AgentToluene diisocyanate (TDI)
Occupation Workers in general population
Outcome/DiagnosisOccupational asthma
Activity Intervention Removal from exposure (6 months)
Participation RateLimitation: no report of participation rate
Intervention EffectivenessThickness of reticular basement membrane was reduced in all subjects (n=6) at follow-up (p<0.05), to values similar of those for non-asthma control subjects (n=4). Changes in inflammatory cell numbers were not statistically significant. Airway hyperresponsiveness persisted at follow-up in most subjects despite absence of symptoms.
Page last reviewed: February 20, 2020