Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
Study Year1993
Molecular Weight of AgentLMW
Agent CategoryDiisocyanates
Specific AgentToluene diisocyanate (TDI)
Occupation Workers in general population
Outcome/DiagnosisOccupational asthma
Activity Intervention Removal from exposure, transfer to low exposure area, respiratory protection (5 years)
Participation Rate60 of 65 eligible subjects (Participation rate: 92%)
Intervention EffectivenessFor subjects who transferred (n=17), there were decreases in FEV1 (p<0.01) and PD15 (p<0.001), and increases in symptom score (p<0.001) and medication use (p<0.001). For subjects who ceased exposure (n=43), there was a decrease in symptom score (p<0.001), and an increase in PD15 (p<0.001). More than half (n=22) of those removed from exposure had recovered or improved at follow-up.
Page last reviewed: February 20, 2020