Prevention of Work-related Asthma: Study Search

Prevention LevelSecondary
Study Year1994
Molecular Weight of AgentLMW
Agent CategoryMetals
Specific AgentPlatinum
Occupation Platinum refinery workers
Outcome/DiagnosisOccupational asthma
Activity Intervention Removal from exposure (mean: 19 months)
Participation RateLimitation: no report of participation rate
Intervention EffectivenessAsthma was still present in 17 of 24 subjects at follow-up, with 22 of 24 subjects showing bronchial hyperresponsiveness. Nonspecific and specific bronchial responsiveness, and FEV1 did not change. Total serum IgE decreased significantly (p<0.005). No association was observed between change in bronchial responsiveness and smoking, time from onset of symptoms to removal, time from removal to follow-up, skin sensitization, or total IgE.
Page last reviewed: February 20, 2020