Prevention of Work-related Asthma: Study Search

Prevention LevelPrimary
Study Year1997
Molecular Weight of AgentHMW
Agent CategoryBiological enzyme
Specific AgentDetergent enzyme
Occupation Detergent industry workers
Outcome/DiagnosisEnzyme sensitization, respiratory symptoms, respiratory incidents
Activity Intervention Encapsulation of enzyme (1970s), compliance with operational enzyme guidelines (1980s), use of new proteolytic enzyme (1986), control of short-duration peak exposures, training, and medical monitoring Medical monitoring, which took place preexposure and annually thereafter, included: skin-prick test, pulmonary function test, respiratory questionnaire. Multicause analysis was used for sensitization cases.
Participation RateLimitation: no report of participation rate
Intervention EffectivenessFrom one company's experience, 7.2% of the exposed population became sensitized from 1986 to 1995, with respiratory indicents ranging from 0 to 0.03% from 1990 to 1995. Mean plant enzyme dust level was 3.0 ng protein/m3 in 1995. This experience is in comparison to that of the general industry during the early 1970's, when the prevalence of sensitization and respiratory incidents were 40% and 15%, respectively, and the mean plant enzyme dust level was 12,000 ng protein/m3.
Page last reviewed: February 20, 2020