| Primary |
| Schweigert |
| 2000 |
| Latin america, North America |
| HMW |
| Biological enzyme |
| Detergent enzyme |
| Detergent industry workers (Includes cohort reported by Peters, 1997) |
| Occupational asthma |
| Encapsulation of enzyme, compliance with operational enzyme guidelines, education and training, medical monitoring (use of skin prick test as screening method) |
| Limitation: no report of participation rate |
| Keeping rates of sensitization less than 3% per enzyme per year effectively eliminated new cases of OA since 1994, when this model was implemented, through 1997. Atopy exclusion had little impact. |
