Prevention of Work-related Asthma: Study Search Results

Study Details

Prevention Level	Secondary
Author	Lemiere C
Study Year	2010
Country	Canada
Molecular Weight of Agent	Both
Category	Various
Agent	N/A
Occupation	N/A
Outcome/Diagnosis	Occupational Asthma
Activity Intervention	Removal from Exposure (four years follow up)
Participation Rate	24 subjects participated in the study
Intervention Effectiveness	<ol><li>Overall, clinical (symptom score, asthma quality of life and rescue use of short-acting beta-2 agonists) and functional characteristics remined stable during the four-year follow-up.</li> <li> The mean dose of ICS decreased from 73.86&plusmn562.0 ug/day at baseline to 294.7&plusmn529.8 ug/day four years later.</li> <li> There was a significant improvement in PC20 over the four-year follow-up period (p=0.03).</li> <li> The Eos counts decreased rapidly in the vast majority of subject</li><li> For two groups of subjects: low (<2%, Eos-) or high (=2%, Eos+) Eos counts after exposure to the offending agent.</li></ol> <ul><li> The Eos+ group had a stable FEV.</l <li> The Eos+ group significantly decreased their dos of inhaled cortlcosteroids(ICS) (P=0.04) and had a trend toward an improvement of airway responsiveness.</li> <li> The Eos- group showed a decrease in FEV1, without any improvement in their functional parameters.</li> <li> The Eos- group had an increase in sputum neutrophils after exposure to the occupational agent as well as during the follow-up period.</li></ul>