Secondary |
Di Giampaolo L |
2012 |
Italy |
Both |
Various |
Latex, manzonia wood, red cedar, cat epithelium, wheat flour |
N/A |
Pulmonary function in allergic occupational asthma (OA) workers |
Exposure cessation or reduction (12 years follow up) |
58 subjects participated in the study, all with allergic OA |
30 workers with complete cessation of exposure to the sensitizing allergens (group A):
• The median FEV1/h3 x hr decline was significantly greater than predicted value (P<0.05)
• The final FEV1 loss was 332.5 ± 108ml
28 workers with reduction in exposure to the sensitizing allergens (group B):
• The median FEV1/h3 x hr decline was significantly greater than predicted value (P<0.03)
• The FEV1/h3 x hr decline was significantly greater in ex-smoker than non-smoker patients (P<0.03)
• There was a significant difference in FEV1/h3/y decay slopes between FEV1 variability >15% and <15% as determined in the first year of observation
• The final FEV1 loss was 512.5 ± 180ml
There was a significant difference in FEV1 loss between two groups after 4 years from cessation of the exposure.
The authors concluded that cessation of workplace allergen exposure was more effective than reduction in limiting pulmonary function decline in workers with OA |