Secondary |
Sjostedt |
1998 |
Denmark |
HMW |
Animal-derived antigens |
Laboratory animal allergen |
Laboratory animal handlers (Includes cohort reported by Willers, 1992) |
Occupational asthma, rhinitis |
Redesign of animal stables, filter top cages, installation of ventilation airflow systems, education and training, personal protective devices (7 years) |
35 of 51 eligible subjects (Participation rate: 69%) |
No subjects developed additional positive skin prick test to laboratory animals. Sensitized workers at baseline were more likely to have stopped working than non-sensitized workers. Subjects sensitized to laboratory animals had a minor increase in airway responsiveness at follow-up (p=0.03). |