Secondary |
Grammer |
1996 |
USA |
LMW |
Anhydrides |
hexahydrophthalic anhydride (HHPA) |
Workers who manufacture resin requiring use of HHPA (Included cohort reported by Grammer, 1995) |
Occupational asthma, allergic rhinitis, occupational asthma-rhinitis, hemorrhagic rhinitis |
Medical surveillance, removal from exposure (> 1 year) Medical surveillance consisted of symtpom questionnaire, physical examination, spirometry, chest film, and immunological assays at diagnosis and at follow-up. |
Study population consisted of 28 employees identified over a 4-year surveillance period |
Of 28 subjects, symptoms and spirometry normalized in all except except one who had mild asthma. Statistically significant declines in IgE and IgG were also observed at follow-up. Limitation: no comparison group. |