Prevention of Work-related Asthma: Study Search Results

Study Details

Prevention Level	Secondary
Author	Nielsen
Study Year	1992
Country
Molecular Weight of Agent	LMW
Category	Anhydrides
Agent	Methyltetrahydrophthalic anhydride (MTHPA)
Occupation	Plant workers producing various plastic products exposed to epoxy resin (Includes cohort reported by Welinder, 1990)
Outcome/Diagnosis	Sensitization and symptoms
Activity Intervention	Reduction in exposure (exhaust ventilation), Removal from exposure (median: 2.7 years)
Participation Rate	41 of 55 eligible subjects (Participation rate: 75%)
Intervention Effectiveness	No statistically significant decreases were found for atopy, symptoms, and bronchial reactivity. Of the 41 subjects, 5 sensitized subjects were removed from exposure, with none having complaints of symptoms, and all showing lower bronchial reactivity (p=0.02). Of the 41 subjects, 7 sensitized subjects continued to work in the reduced-exposure environment. One of the 7 reported less symptoms with less bronchial reactivity.