Secondary |
Grammer |
1993 |
USA |
LMW |
Anhydrides |
Trimelletic anhydride (TMA) |
Workers manufacturing TMA (Includes cohort reported by Zeiss, 1977) |
Late asthma, asthma-rhinitis |
Transfer to low exposure area (median: 8 years, late asthma; 9.5 years, asthma-rhinitis) |
Limitation: no report of participation rate |
Seven of 12 subjects with asthma-rhinitis continued to have moderate or severe symptoms, abnormal pulmonary function, and elevated IgE. All subjects with late asthma (n=3) improved in symptoms, pulmonary function, and IgE. Limitation: no comparison group. |