Secondary |
Pisati |
1993 |
Italy |
LMW |
Diisocyanates |
Toluene diisocyanate (TDI) |
Workers in general population |
Occupational asthma |
Removal from exposure, transfer to low exposure area, respiratory protection (5 years) |
60 of 65 eligible subjects (Participation rate: 92%) |
For subjects who transferred (n=17), there were decreases in FEV1 (p<0.01) and PD15 (p<0.001), and increases in symptom score (p<0.001) and medication use (p<0.001). For subjects who ceased exposure (n=43), there was a decrease in symptom score (p<0.001), and an increase in PD15 (p<0.001). More than half (n=22) of those removed from exposure had recovered or improved at follow-up. |