Prevention of Work-related Asthma: Study Search Results

Study Details

Prevention Level	Secondary
Author	Merget
Study Year	1994
Country	Germany
Molecular Weight of Agent	LMW
Category	Metals
Agent	Platinum
Occupation	Platinum refinery workers
Outcome/Diagnosis	Occupational asthma
Activity Intervention	Removal from exposure (mean: 19 months)
Participation Rate	Limitation: no report of participation rate
Intervention Effectiveness	Asthma was still present in 17 of 24 subjects at follow-up, with 22 of 24 subjects showing bronchial hyperresponsiveness. Nonspecific and specific bronchial responsiveness, and FEV1 did not change. Total serum IgE decreased significantly (p<0.005). No association was observed between change in bronchial responsiveness and smoking, time from onset of symptoms to removal, time from removal to follow-up, skin sensitization, or total IgE.