An illness characterized by diarrhea and/or vomiting; severity is variable.
A clinically compatible illness that is laboratory confirmed
When other cases are known to be occurring, a less than fourfold increase in titer between acute- and convalescent-phase serum may be considered significant. Likewise, a less than fourfold decrease in titer between early and late convalescent-phase sera may be important in these circumstances. Illnesses caused by strains of V. cholerae other than toxigenic V. cholerae O1 or O139 should not be reported as cases of cholera. The etiologic agent of a case of cholera should be reported as either V. cholerae O1 or V. cholerae O139. Note: Only confirmed cases should be reported by state health departments to the National Notifiable Diseases Surveillance System (NNDSS).