Infection may be asymptomatic or may produce an acute or chronic disease. Although the disease initially resembles an influenza-like febrile illness primarily involving the bronchopulmonary system, dissemination can occur to virtually any organ system. Confirmation of coccidioidomycosis requires the demonstrated presence of Coccidioides immitis by histopathologic, cultural, or molecular means; and/or demonstration of a specific immunologic response (i.e., skin test conversion or demonstration of presence of coccidioidal antibody). The results of these immunologic tests must be interpreted in the context of the varied clinical presentations and the duration and clinical type of coccidioidomycosis.
An illness characterized by one or more of the following:
Laboratory-confirmed coccidioidomycosis requires one or more of the following:
A case that meets the clinical criteria and is laboratory confirmed.