Perinatal hepatitis B in the newborn may range from asymptomatic to fulminant hepatitis.
Hepatitis B surface antigen (HBsAg) positive
HBsAg positivity in any infant aged >1-24 months who was born in the United States or in U.S. territories to an HBsAg-positive mother
Infants born to HBsAg-positive mothers should receive hepatitis B immune globulin (HBIG) and the first dose of hepatitis B vaccine within 12 hours of birth, followed by the second and third doses of vaccine at 1 and 6 months of age, respectively. Post-vaccination testing for HBsAg and anti-HBs (antibody to HBsAg) is recommended from 3 to 6 months following completion of the vaccine series. If HBIG and the initial dose of vaccine are delayed for >1 month after birth, testing for HBsAg may determine if the infant is already infected. The 1995 case definition appearing on this page was re-published incorrectly in the 1997 MMWR Recommendations and Reports titled Case Definitions for Infectious Conditions Under Public Health Surveillance.1 Thus, the 1995 and the 1997 versions of this case definition are not identical, and the 1995 version is the correct one.