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Hepatitis C, Acute
2011 Case Definition

NOTE: A surveillance case definition is a set of uniform criteria used to define a disease for public health surveillance. Surveillance case definitions enable public health officials to classify and count cases consistently across reporting jurisdictions. Surveillance case definitions are not intended to be used by healthcare providers for making a clinical diagnosis or determining how to meet an individual patient’s health needs.

CSTE Position Statement(s)

  • 10-ID-08

Clinical Description

An acute illness with a discrete onset of any sign or symptom consistent with acute viral hepatitis (e.g., anorexia, abdominal discomfort, nausea, vomiting), and either a) jaundice/dark urine, or b) serum alanine aminotransferase (ALT) levels >400 IU/L.

Laboratory Criteria for Diagnosis

One or more of the following three criteria:

  • Antibodies to hepatitis C virus (anti-HCV) screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay as defined by CDC. (URL for the signal to cut-off ratios: https://www.cdc.gov/hepatitis/HCV/LabTesting.htm), OR
  • Hepatitis C Virus Recombinant Immunoblot Assay (HCV RIBA) positive, OR
  • Nucleic Acid Test (NAT) for HCV RNA positive (including genotype)
AND, meets the following two criteria:
  • Immunoglulin M antibody to hepatitis A virus (IgM anti-HAV) negative, AND
  • IgM antibody to hepatitis B core antigen (IgM anti-HBc) negative

Case Classification

Confirmed

A case that meets the clinical case definition, is laboratory confirmed, and is not known to have chronic hepatitis C.



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