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Hepatitis C, Chronic
2010 Case Definition

CSTE Position Statement(s)

  • 09-ID-41

Clinical Description

Most hepatitis C virus (HCV)-infected persons are asymptomatic; however, many have chronic liver disease, which can range from mild to severe including cirrhosis and liver cancer.

Laboratory Criteria for Diagnosis

One or more of the following criteria:

  • Anti-HCV positive (repeatedly reactive) by enzyme immunoassay (EIA) verified by at least one additional more specific assay, OR
  • HCV-RIBA (recombinant immunoblot assay) positive, OR
  • Nucleic Acid Test (NAT) for HCV RNA positive, OR
  • Report of HCV genotype, OR
  • Antibodies to hepatitis C virus (anti-HCV) screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay and posted by CDC.1

Case Classification


A case that is anti-HCV positive (repeat reactive) by EIA and has alanine aminotransferase (ALT or serum glutamic pyruvic transaminase [SGPT]) values above the upper limit of normal, but the anti-HCV EIA result has not been verified by an additional more specific assay or the signal to cut-off ratio is unknown.


A case that is laboratory confirmed and does not meet the case definition for acute hepatitis C.


  1. Centers for Disease Control and Prevention [Internet]. Viral Hepatitis. [cited 2010 Sept 30]. Available from