Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Hepatitis C, Past or Present
2011 Case Definition

CSTE Position Statement(s)

  • 10-ID-09

Clinical Description

No symptoms are required. Most hepatitis C virus (HCV)-infected persons are asymptomatic; however, many have chronic liver disease, which can range from mild to severe.

Laboratory Criteria for Diagnosis

One or more of the following four criteria:

  • Antibodies to hepatitis C virus (Anti–HCV) positive (repeatedly reactive) by enzyme immunoassay (EIA) verified by at least one additional more specific assay, OR
  • Hepatitis C virus recombinant immunoblot assay (HCV RIBA) positive, OR
  • Nucleic acid test (NAT) positive for HCV RNA (including genotype), OR
  • Anti-HCV screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay and posted by CDC. (

Case Classification


A case that is anti-HCV positive (repeat reactive) by EIA and has alanine aminotransferase (ALT or serum glutamic pyruvic transaminase [SGPT]) values above the upper limit of normal, but the anti-HCV EIA result has not been verified by an additional more specific assay or the signal to cut-off ratio is unknown.


A case that is laboratory confirmed and does not meet the case definition for acute hepatitis C.