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Rabies, Human
2010 Case Definition

CSTE Position Statement(s)

  • 09-ID-70

Clinical Description

Rabies is an acute encephalomyelitis that almost always progresses to coma or death within 10 days after the first symptom.

Laboratory Criteria for Diagnosis

  • Detection by direct fluorescent antibody of viral antigens in a clinical specimen (preferably the brain or the nerves surrounding hair follicles in the nape of the neck), OR
  • Isolation (in cell culture or in a laboratory animal) of rabies virus from saliva, cerebrospinal fluid (CSF), or central nervous system tissue, OR
  • Identification of a rabies-neutralizing antibody titer greater than or equal to 5 (complete neutralization) in CSF, OR
  • Identification of a rabies-neutralizing antibody titer greater than or equal to 5 (complete neutralization) in the serum of an unvaccinated person.

Case Classification

Confirmed

A clinically compatible case that is laboratory confirmed

Comments

Laboratory confirmation by all of the above methods is strongly recommended.



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