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Reye Syndrome
1990 Case Definition

Clinical Criteria

An illness that meets all of the following criteria:

  • Acute, noninflammatory encephalopathy that is documented clinically by a) an alteration in consciousness and, if available, b) a record of the cerebrospinal fluid (CSF) containing less than or equal to 8 leukocytes/ or a histologic specimen demonstrating cerebral edema without perivascular or meningeal inflammation
  • Hepatopathy documented by either a) a liver biopsy or an autopsy considered to be diagnostic of Reye syndrome or b) a threefold or greater increase in the levels of the serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), or serum ammonia
  • No more reasonable explanation for the cerebral and hepatic abnormalities

Case Classification


A case that meets the clinical criteria