Staphylococcus aureus can produce a variety of syndromes with clinical manifestations including skin and soft tissue infections, empyema, bloodstream infection, pneumonia, osteomyelitis, septic arthritis, endocarditis, sepsis, and meningitis. S. aureus may also colonize individuals who remain asymptomatic. The most frequent site of S. aureus colonization is the nares.
A case of vancomycin-intermediate or vancomycin-resistant S. aureus that is laboratory-confirmed (MIC=4-8 µg/ml for VISA and MIC≥16 µg/ml for VRSA).
The 2007 case definition appearing on this page was re-published in the 2009 CSTE position statement 09-ID-58 and 09-ID-59. Thus, the 2007 and 2010 versions of the case definition are identical.