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AR Gene Glossary

The AR gene glossary describes the molecular mechanisms of resistance represented in the AR Isolate Bank.


Allele Variant Antibiotic Class Genbank Accession Product Annotation
aac(2')-Iaaac(2')-Ia_1Aminoglycoside resistanceL06156aminoglycoside 2'-N-acetyltransferase
aac(3)-Iaaac(3)-Ia_1Aminoglycoside resistanceX15852unnamed protein product; aacC1 product acetyltransferase (AA 1-177)"
aac(3)-Ibaac(3)-Ib_1Aminoglycoside resistanceL06157aminoglycoside 3'-N-acetyltransferase
aac(3)-Icaac(3)-Ic_1Aminoglycoside resistanceAJ511268aminoglycoside acetyltransferase
aac(3)-Idaac(3)-Id_1Aminoglycoside resistanceAB114632aminoglycoside acetyltransferase
aac(3)-IIaaac(3)-IIa_1Aminoglycoside resistanceX51534unnamed protein product; AAC(3)-II (AA 1-286)
aac(3)-IIdaac(3)-IId_1Aminoglycoside resistanceEU022314aminoglycoside-(3)-N-acetyl-transferase
aac(6')-33aac(6')-33_1Aminoglycoside resistanceGQ337064aminoglycoside acetyltransferase
aac(6')-aph(2'')aac(6')-aph(2'')_1Aminoglycoside resistanceM13771AAC(6')-APH(2') bifunctional resistance protein
aac(6')-Ibaac(6')-Ib_1Aminoglycoside resistanceM21682aminoglycoside 6'-N-acetyltransferase
aac(6')Ib-craac(6')Ib-cr_1Fluoroquinolone and aminoglycoside resistanceDQ303918fluroquinolone acetylating aminoglycoside acetyltransferase
aac(6')-Icaac(6')-Ic_1Aminoglycoside resistanceM94066aminoglycoside acetyltransferase
aac(6')-Ifaac(6')-If_1Aminoglycoside resistanceX55353AG-6'-acetyltransferase
aac(6')-IIaaac(6')-IIa_1Aminoglycoside resistanceM296956'-N-acetyltransferase
aac(6')-IIcaac(6')-IIc_1Aminoglycoside resistanceAF162771aminoglycoside 6'-N-acetyltransferase
aadA1aadA1_4Aminoglycoside resistanceM95287aminoglycoside (3' ') adenylyltransferase
aadA1aadA1_5Aminoglycoside resistanceJQ480156aminoglycoside-adenyltransferase
aadA11aadA11_1Aminoglycoside resistanceAY144590aminoglycoside adenylyltransferase
aadA2aadA2_2Aminoglycoside resistanceJQ364967aminoglycosides adenyltransferase
aadA5aadA5_1Aminoglycoside resistanceAF137361streptomycin and spectinomycin resistance aminoglycoside adenyltransferase
aadA6aadA6_1Aminoglycoside resistanceAF140629aminoglycoside adenylyltransferase AADA6
aadA7aadA7_1Aminoglycoside resistanceAF224733aminoglycoside adenylyltransferase
aadBaadB_1Aminoglycoside resistanceJN119852aminoglycoside-2''-adenylyltransferase"
aadDaadD_1Aminoglycoside resistanceAF181950kanamycin resistance protein
ACT-15ACT-15_1Beta-lactam resistance:AmpC-typeJX440356AmpC beta-lactamase ACT-15
ACT-16ACT-16_1Beta-lactam resistance:AmpC-typeAB737978beta lactamase ACT-16
ACT-5ACT-5_1Beta-lactam resistance:AmpC-typeFJ237369beta-lactamase ACT-5
ACT-7ACT-7_1Beta-lactam resistance:AmpC-typeFJ237368beta-lactamase EBC-1464
ADC-25ADC-25_1Beta-lactam resistanceEF016355AmpC cephalosporinase
aph(3')-Iaaph(3')-Ia_1Aminoglycoside resistanceV00359
aph(3')-Icaph(3')-Ic_1Aminoglycoside resistanceX62115neomycin phosphotransferase
aph(3')-IIbaph(3')-IIb_1Aminoglycoside resistanceX90856aminoglycoside phosphotransferase (3')IIps
aph(3')-IIIaph(3')-III_1Aminoglycoside resistanceM26832kanamycin resistance protein
aph(3')-VIaaph(3')-VIa_1Aminoglycoside resistanceX07753
aph(3')-XVaph(3')-XV_1Aminoglycoside resistanceY18050aminoglycoside phosphotransferase
aph(4)-Iaaph(4)-Ia_1Aminoglycoside resistanceV01499unnamed protein product; aph(4)
armAarmA_1Aminoglycoside resistanceAY22055816S rRNA methylase
ARR-3ARR-3_4Rifampicin resistanceFM207631rifampicin ADP-ribosylatin transferase
blaZblaZ_34Beta-lactam resistanceAP003139beta-lactamase
blaZblaZ_35Beta-lactam resistanceAJ302698beta-lactamase
blaZblaZ_36Beta-lactam resistanceAJ400722beta-lactamase
catA1catA1_1Phenicol resistanceV00622
catA3catA3_1Phenicol resistanceX07848
catB2catB2_1Phenicol resistanceAF047479chloramphenicol acetyltransferase
catB3catB3_1Phenicol resistanceAJ009818Chloramphenicol acetyltransferase
catB7catB7_1Phenicol resistanceAF036933chloramphenicol acetyltransferase
catB8catB8_1Phenicol resistanceAF227506chloramphenicol acetyltransferase
cmlA1cmlA1_1Phenicol resistanceM64556nonenzymatic chloramphenicol-resistance protein
cmlA1cmlA1_2Phenicol resistanceAB212941chloramphenicol resistance
cmxcmx_1Phenicol resistanceU85507chloramphenicol resistance protein
CMY-2CMY-2_1Beta-lactam resistanceX91840extended spectrum beta-lactamase
CMY-4CMY-4_1Beta-lactam resistanceAF420597cephamycinase
CMY-42CMY-42_1Beta-lactam resistanceHM146927AmpC beta-lactamase
CMY-6CMY-6_1Beta-lactam resistanceAJ011293beta-lactamase
CMY-76CMY-76_1Beta-lactam resistanceJQ733573AmpC beta-lactamase CMY-76
CMY-79CMY-79_1Beta-lactam resistanceJQ733576AmpC beta-lactamase CMY-79
CMY-80CMY-80_1Beta-lactam resistanceJQ733577AmpC beta-lactamase CMY-80
CMY-84CMY-84_1Beta-lactam resistanceJQ733579AmpC beta-lactamase CMY-84
CMY-94CMY-94_1Beta-lactam resistanceJX514368CMY-like beta-lactamase
CTX-M-124CTX-M-124_1Beta-lactam resistanceJQ429324extended-spectrum beta-lactamase CTX-M-124
CTX-M-14CTX-M-14_1Beta-lactam resistanceAF252622beta-lactamase CTX-M-14
CTX-M-15CTX-M-15_23Beta-lactam resistanceDQ302097extended-spectrum beta-lactamase CTX-M-15
CTX-M-2CTX-M-2_1Beta-lactam resistanceEU622041resistance to beta-lactams including extended-spectrum cephalosporins
CTX-M-55CTX-M-55_2Beta-lactam resistanceGQ456159extended-spectrum beta-lactamase CTX-M-55
dfrA1dfrA1_1Trimethoprim resistanceX00926dihydrofolate reductase (DHFR)
dfrA1dfrA1_30Trimethoprim resistanceJQ690541dihydrofolate reductase type I
dfrA12dfrA12_1Trimethoprim resistanceAB571791dihydrofolate reductase
dfrA14dfrA14_1Trimethoprim resistanceDQ388123dihydrofolate reductase
dfrA15dfrA15_1Trimethoprim resistanceHM449019dihydrofolate reductase
dfrA17dfrA17_1Trimethoprim resistanceFJ460238dihydrofolate reductase; trimethoprim resistance
dfrA18dfrA18_1Trimethoprim resistanceAJ310778dihydrofolate reductase
dfrA29dfrA29_1Trimethoprim resistanceAM237806dihydrofolate reductase type VII
dfrA30dfrA30_1Trimethoprim resistanceAM997279dihydrofolate reductase
dfrA3bdfrA3b_1Trimethoprim resistanceAY878717dihydrofolate reductase type IIIb
dfrA5dfrA5_1Trimethoprim resistanceX12868
dfrA8dfrA8_1Trimethoprim resistanceU10186dihydrofolate reductase type VIII
dfrB1dfrB1_2Trimethoprim resistanceU36276dihydrofolate reductase
dfrB5dfrB5_1Trimethoprim resistanceAY943084dihydrofolate reductase
dfrGdfrG_1Trimethoprim resistanceAB205645dihydrofolate reductase
DHA-1DHA-1_1Beta-lactam resistance:AmpC-typeY16410beta-lactamase class C
ere(A)ere(A)_2Macrolide resistanceAF099140erythromycin esterase
erm(42)erm(42)_2Macrolide resistanceAB601890erythromycin resistance protein
erm(A)erm(A)_1Macrolide resistanceX03216
erm(B)erm(B)_1Macrolide resistanceJN899585rRNA methylase
fosAfosA_10Fosfomycin resistanceEU195449putative fosfomycin-resistance protein
fosAfosA_13Fosfomycin resistanceEU487198fosfomycin-resistance protein
fosAfosA_14Fosfomycin resistanceAB522970fosfomycin resistance protein FosA3
fosAfosA_3Fosfomycin resistanceNZ_ACWO01000079
fosAfosA_7Fosfomycin resistanceNZ_AFBO01000747
GES-1GES-1_1Beta-lactam resistanceHQ170511extended-spectrum beta-lactamase GES-7
IMP-1IMP-1_1Beta-lactam resistanceDQ522237metallo-beta-lactamase IMP-1-like
IMP-14IMP-14_1Beta-lactam resistanceAY553332metallo-beta-lactamase; carbapenemase IMP-14
IMP-4IMP-4_1Beta-lactam resistanceAF244145carbapenem-hydrolysing beta-lactamase
KPC-2KPC-2_1Beta-lactam resistanceAY034847carbapenemase
KPC-3KPC-3_1Beta-lactam resistanceHM769262beta-lactamase KPC-3
KPC-4KPC-4_1Beta-lactam resistanceFJ473382beta-lactamase KPC-4
KPC-5KPC-5_1Beta-lactam resistanceEU400222beta-lactamase KPC-5
KPC-6KPC-6_1Beta-lactam resistanceEU555534beta-lactamase KPC-6
LEN16LEN16_1Beta-lactam resistanceAY743416LEN-type penicillinase
MAL-1MAL-1_1Beta-lactam resistanceAJ277209beta-lactamase MAL-1
MAL-1MAL-1_2Beta-lactam resistanceAJ609506class A beta-lactamase
mcr-1mcr-1_1Colistin resistanceKP347127phosphoethanolamine transferase
mecAmecA_14Beta-lactam resistanceAB505630penicillin-binding protein 2'
mecAmecA_15Beta-lactam resistanceAB505628penicillin-binding protein 2'
mecAmecA_6Beta-lactam resistanceFR821779beta-lactam-inducible penicillin-binding protein
mph(A)mph(A)_1Macrolide resistanceD16251macrolide 2'-phosphotransferase I
mph(C)mph(C)_2Macrolide resistanceAF167161
mph(E)mph(E)_3Macrolide resistanceEU294228macrolide 2'-phosphotransferase
msr(A)msr(A)_3Macrolide, Lincosamide and Streptogramin B resistanceM8180221kDa product of the C-terminal of MsrB
msr(E)msr(E)_4Macrolide, Lincosamide and Streptogramin B resistanceEU294228
NDM-1NDM-1_1Beta-lactam resistanceFN396876metallo-beta-lactamase
NDM-5NDM-5_1Beta-lactam resistanceJN104597NDM-5 metallo-beta-lactamase
NDM-6NDM-6_1Beta-lactam resistanceJN967644NDM carbapenemase
NDM-7NDM-7_1Beta-lactam resistanceJX262694NDM-7 metallo-beta-lactamase
NMC-ANMC-A_1Beta-lactam resistanceAJ536087class A nonmetallocarbapenamase
OKP-B-2OKP-B-2_1Beta-lactam resistanceAM051151OKP-B beta-lactamase
oqxAoqxA_1Quinolone resistanceEU370913component of RND-type multidrug efflux pump that confers resistance to olaquindox
oqxBoqxB_1Quinolone resistanceEU370913component of RND-type multidrug efflux pump that confers resistance to olaquindox
OXA-1OXA-1_1Beta-lactam resistanceJ02967OXA-1 beta-lactamase
OXA-10OXA-10_2Beta-lactam resistanceEU886981Beta-lactamase
OXA-100OXA-100_1Beta-lactam resistanceAM231720blaOXA-100 class D beta-lactamase
OXA-181OXA-181_1Beta-lactam resistanceHM992946carbapenemase OXA-181
OXA-2OXA-2_1Beta-lactam resistanceDQ310703oxacillinase type 2
OXA-203OXA-203_1Beta-lactam resistanceHQ998857beta-lactamase OXA-203
OXA-223OXA-223_1Beta-lactam resistanceJN248564beta-lactamase OXA-223
OXA-23OXA-23_1Beta-lactam resistanceHQ700358beta-lactamase OXA-23
OXA-232OXA-232_1Beta-lactam resistanceJX423831class D beta-lactamase
OXA-237OXA-237_1Beta-lactam resistanceJQ820241beta-lactamase OXA-237
OXA-24OXA-24_1Beta-lactam resistanceAJ239129Beta-lactamase
OXA-4OXA-4_1Beta-lactam resistanceAY162283beta-lactamase OXA-4
OXA-48OXA-48_2Beta-lactam resistanceAY236073class D carbapenem-hydrolyzing beta-lactamase
OXA-50OXA-50_1Beta-lactam resistanceAY306135oxacillinase
OXA-50OXA-50_2Beta-lactam resistanceAY306133oxacillinase
OXA-50OXA-50_3Beta-lactam resistanceAY306130oxacillinase
OXA-50OXA-50_3Beta-lactam resistanceAY306132oxacillinase
OXA-56OXA-56_1Beta-lactam resistanceAY660529restricted spectrum class D beta-lactamase
OXA-58OXA-58_1Beta-lactam resistanceAY665723carbapenem-hydrolyzing oxacillinase
OXA-64OXA-64_1Beta-lactam resistanceAY750907beta-lactamase OXA-64
OXA-65OXA-65_1Beta-lactam resistanceAY750908beta-lactamase OXA-65
OXA-66OXA-66_4Beta-lactam resistanceFJ360530OXA carbapenemase; class D oxacillinase
OXA-69OXA-69_1Beta-lactam resistanceHM564339carbapenem-hydrolyzing oxacillinase OXA-69
OXA-71OXA-71_1Beta-lactam resistanceAY859528carbapenem-hydrolyzing oxacillinase OXA-71
OXA-72OXA-72_1Beta-lactam resistanceGU199039class D beta-lactamase OXA-72
OXA-82OXA-82_1Beta-lactam resistanceGQ352402beta-lactamase OXA-82 protein
OXA-9OXA-9_2Beta-lactam resistanceJF703130oxacillinase-carbenicillinase
OXA-94OXA-94_1Beta-lactam resistanceDQ519088beta-lactamase OXA-94
OXY-1-4OXY-1-4_4Beta-lactam resistanceAY077483K1 beta-lactamase
OXY-1-7OXY-1-7_7Beta-lactam resistanceM27459beta-lactamase
OXY-2-8OXY-2-8_8Beta-lactam resistanceAY055205K1 beta-lactamase OXY-2
PAOPAO_1Beta-lactam resistanceAY083595beta-lactamase precursor
PAOPAO_2Beta-lactam resistanceFJ666065class C beta-lactamase PDC-1
PAOPAO_3Beta-lactam resistanceFJ666073class C beta-lactamase PDC-10
PAOPAO_4Beta-lactam resistanceAY083592beta-lactamase precursor
PER-7PER-7_1Beta-lactam resistanceHQ713678extended spectrum beta-lactamase
QnrB13QnrB13_1Quinolone resistanceEU273755quinolone resistance protein; pentapeptide repeat protein
QnrB2QnrB2_1Quinolone resistanceHM125698fluoroquinolone resistance protein
QnrB34QnrB34_1Quinolone resistanceJN173056quinolone resistance protein QnrB34
QnrB38QnrB38_1Quinolone resistanceJN173060QnrB38
QnrB4QnrB4_1Quinolone resistanceDQ303921contains pentapeptide repeat
QnrB5QnrB5_1Quinolone resistanceDQ303919contains pentapeptide repeat
QnrB6QnrB6_3Quinolone resistanceEF523819QnrB6
QnrB7QnrB7_1Quinolone resistanceEU043311QnrB7
QnrS1QnrS1_1Quinolone resistanceAB187515Qnr
rmtBrmtB_1Aminoglycoside resistanceAB10350616S rRNA methylase
rmtCrmtC_1Aminoglycoside resistanceAB19477916S rRNA methylase
rmtfrmtf_1Aminoglycoside resistanceJQ808129aminoglycoside 16s rRNA methyltransferase
rmtGrmtG_1Aminoglycoside resistanceKJ00456716S rRNA methyltransferase
SFO-1SFO-1_1Beta-lactam resistanceAB003148class A beta-lactamase SFO-1
SHV-1SHV-1_11Beta-lactam resistanceEF035565extended spectrum beta lactamase
SHV-1SHV-1_13Beta-lactam resistanceAF462396extended-spectrum beta-lactamase SHV-1
SHV-1SHV-1_18Beta-lactam resistanceFJ668818beta-lactamase SHV-1
SHV-1SHV-1_9Beta-lactam resistanceHM751102SHV-1 beta-lactamase
SHV-11SHV-11_10Beta-lactam resistanceEF035557extended spectrum beta lactamase
SHV-11SHV-11_15Beta-lactam resistanceDQ219473extended-spectrum beta-lactamase SHV-11
SHV-11SHV-11_1Beta-lactam resistanceAY528717beta-lactamase
SHV-11SHV-11_2Beta-lactam resistanceHM751098SHV-11 beta-lactamase
SHV-11SHV-11_5Beta-lactam resistanceGQ407117beta-lactamase blaSHV-11
SHV-11SHV-11_8Beta-lactam resistanceGQ387358beta-lactamase SHV-11
SHV-11SHV-11_9Beta-lactam resistanceFJ483937beta-lactamase SHV-11
SHV-12SHV-12_1Beta-lactam resistanceAF462395extended-spectrum beta-lactamase SHV-12
SHV-26SHV-26_1Beta-lactam resistanceAF227204beta-lactamase
SHV-30SHV-30_1Beta-lactam resistanceAY661885beta-lactamase SHV-30
SHV-5SHV-5_6Beta-lactam resistanceEF653399beta-lactamase SHV-5
SHV-83SHV-83_1Beta-lactam resistanceAM176558beta-lactamase
SME-3SME-3_1Beta-lactam resistanceAY584237carbapenem-hydrolyzing beta-lactamase SME-3
spcspc_1Aminoglycoside resistanceX02588
SPM-1SPM-1_1Beta-lactam resistanceAY341249carbapenemase
strAstrA_1Aminoglycoside resistanceM96392
strAstrA_4Aminoglycoside resistanceAF321551aminoglycoside 3''-phosphotransferase
strBstrB_1Aminoglycoside resistanceM96392streptomycin phosphotransferase
sul1sul1_11Sulphonamide resistanceDQ914960dihydropteroate synthase
sul1sul1_2Sulphonamide resistanceCP002151dihydropteroate synthase protein Sul1
sul2sul2_2Sulphonamide resistanceGQ421466dihydropteroate synthase
sul2sul2_3Sulphonamide resistanceHQ840942sulfonamide-insensitive dihydropteroate synthetase
sul3sul3_2Sulphonamide resistanceAJ459418dihydropteroate synthase
TEM-1ATEM-1A_4Beta-lactam resistanceHM749966TEM-1 beta-lactamase
TEM-1BTEM-1B_1Beta-lactam resistanceJF910132beta-lactamase
TEM-1DTEM-1D_83Beta-lactam resistanceAF188200beta-lactamase variant TEM-1D
TEM-52BTEM-52B_1Beta-lactam resistanceAF027199extended spectrum beta-lactamase
tet(A)tet(A)_3Tetracycline resistanceAY196695tetracycline resistance efflux pump
tet(A)tet(A)_4Tetracycline resistanceAJ517790tetracycline resistance protein
tet(B)tet(B)_3Tetracycline resistanceAP000342tetracycline resistance protein
tet(B)tet(B)_4Tetracycline resistanceAF326777tetracycline resistance protein TetA(B)
tet(C)tet(C)_5Tetracycline resistanceNC_003213TetA(C) protein
tet(D)tet(D)_1Tetracycline resistanceAF467077TetA(D); class D; efflux pump
tet(G)tet(G)_4Tetracycline resistanceAF133140tetracycline resistance protein
tet(J)tet(J)_1Tetracycline resistanceACLE01000065transporter, major facilitator family protein
tet(K)tet(K)_4Tetracycline resistanceU38428tetracycline resistance protein
tet(M)tet(M)_7Tetracycline resistanceFN433596tetracycline resistance protein
VEB-1VEB-1_1Beta-lactam resistanceHM370393extended-spectrum beta-lactamase
VIM-1VIM-1_1Beta-lactam resistanceY18050beta-lactamase VIM-1
VIM-11VIM-11_1Beta-lactam resistanceAY605049VIM-11
VIM-2VIM-2_1Beta-lactam resistanceAF302086metallo-beta-lactamase
VIM-27VIM-27_1Beta-lactam resistanceHQ858608metallo-beta-lactamase VIM-27
VIM-4VIM-4_1Beta-lactam resistanceEU581706metallo-beta-lactamase
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