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Panel:   Aspergillus fumigatus (ASP)
AR Bank # 0731 Aspergillus fumigatus
Study ID: ASP-01

Biosample Accession #: Biosample Accession data is not yet available.

   
Location: USA

MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antifungal agent for an isolate may commonly be ± 2 log2 (doubling dilution) different than what is posted on the CDC & FDA AR Isolate Bank website because this is the normal technical variability of antifungal susceptibility testing.

Panel:  Aspergillus fumigatus (ASP)


MIC (μg/ml) Results and Interpretation
Drug MIC (μg/ml) INT
Anidulafungin 0.03---
Caspofungin 0.03---
Isavuconazole >8---
Itraconazole >16---
Micafungin 0.03---
Posaconazole 2---
Voriconazole 4---
Device manufacturers and users of FDA cleared devices shall consult the FDA’s Antibacterial Susceptibility Test Interpretive Criteria       website for breakpoints recognized or recommended by FDA, and for information regarding FDA exceptions or additions to the applicable, recognized consensus standard.
Molecular Mechanisms of Resistance
CategoryGene
Azoles L98H, TR34
 
Disclaimer:
The resistance mechanisms listed were identified by targeted gene sequencing. CYP51 sequence from Aspergillus fumigatus strain 237 (GenBank accession number AF338659) was used as the wild type reference.
Propagation
MEDIUM
Medium: Sabouraud Dextrose agar (SDA)

GROWTH CONDITIONS
Temperature: 30°C
Atmosphere: Aerobic

PROPAGATION PROCEDURE
Remove the sample vial to a container with dry ice or a freezer block. Keep vial on ice or block. (Do not let vial content thaw)
Open vial aseptically to avoid contamination
Using a sterile loop, remove a small amount of frozen isolate from the top of the vial
Aseptically transfer the loop to SDA
Use streak plate method to isolate single colonies
Incubate inverted plate at 30⁰C for 48 hrs.
Storage Temperature & Biosafety
STORAGE TEMPERATURE: -70°C

BIOSAFETY LEVEL: 2
Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the current publication of 'BioSafety in Microbiological and Biomedical Laboratories' from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Institutes of Health.

Disclaimer:
This product is sent with the condition that you are responsible for its safe storage, handling, and use. All materials are the property of the Centers for Disease Control and Prevention (CDC) and have been made available on behalf of the Food and Drug Administration (FDA). This material is not for use in human subjects and may not be redistributed. While CDC uses reasonable efforts to include accurate and up-to-date information on this product sheet, CDC makes no warranties or representations as to its accuracy. CDC is not liable for damages arising from the misidentification or misrepresentation of cultures. Please refer to the Standard Letter Agreement (SLA) for further details regarding the use of this product.
Isolate History
Date Action Performed
04/24/23MIC was updated with a new value for Voriconazole: from '2' to '4'
04/24/23MIC was updated with a new value for Posaconazole: from '---' to '2'
04/24/23MIC was updated with a new value for Micafungin: from '---' to '0.03'
04/24/23MIC was updated with a new value for Itraconazole: from '8' to '>16'
04/24/23MIC was updated with a new value for Isavuconazole: from '---' to '>8'
04/24/23MIC was updated with a new value for Caspofungin: from '---' to '0.03'
04/24/23MIC was updated with a new value for Anidulafungin: from '---' to '0.03'
04/24/23Drug was added: Isavuconazole
04/24/23Drug was added: Posaconazole
04/24/23Drug was added: Micafungin
04/24/23Drug was added: Caspofungin
04/24/23Drug was added: Anidulafungin
10/11/18New Isolate added to panel
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