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AR Bank # 0849 Proteus mirabilis

Biosample Accession #: Biosample Accession data is not yet available.

   


Panel:  Plazomicin


MIC (μg/ml) Results and Interpretation
Drug MIC (μg/ml) INT
Amikacin 4S
Ampicillin >32R
Ampicillin/sulbactam 18S
Aztreonam <=2S
Cefazolin >8R
Cefepime <=0.5S
Cefotaxime <=0.5S
Cefotaxime/clavulanic acid 1<=0.25---
Cefoxitin 8S
Ceftazidime <=1S
Ceftazidime/avibactam 1<=0.5S
Ceftazidime/clavulanic acid 1<=0.5---
Ceftolozane/tazobactam 1<=0.5S
Ceftriaxone <=1S
Ciprofloxacin >8R
Colistin >8R
Doripenem 0.5S
Ertapenem <=0.12S
Gentamicin >16R
Imipenem 4R
Imipenem+chelators 24---
Levofloxacin >8R
Meropenem <=0.12S
Piperacillin/tazobactam 1<=4S
Plazomicin 38R
Tetracycline >32R
Tigecycline 2 34R
Tobramycin 16R
Trimethoprim/sulfamethoxazole 1>8R
S – I –R Interpretation (INT) derived from CLSI 2018 M100 S28
Clinical and PK/PD data demonstrate colistin has limited clinical efficacy, even if an intermediate result is obtained. Alternative agents are strongly preferred. Colistin should be used in combination with one or more active antimicrobial agents. Consultation with an infectious disease specialist is recommended.

1 Reflects MIC of first component
2 Screen for metallo-beta-lactamase production [Rasheed et al. Emerging Infectious Diseases. 2013. 19(6):870-878]
2 The interpretation of resistant is due to intrinsic resistance for this species-drug combination rather than the MIC. Refer to CLSI M100 for more information about intrinsic resistance”
3 Based on FDA break points
Molecular Mechanism of Resistance
CategoryGene
 

Propagation
MEDIUM
Medium: Trypticase Soy Agar with 5% Sheep Blood (BAP)

GROWTH CONDITIONS
Temperature: 35°C
Atmosphere: Aerobic

PROPAGATION PROCEDURE

Remove the sample vial to a container with dry ice or a freezer block. Keep vial on ice or block. (Do not let vial content thaw)

Open vial aseptically to avoid contamination

Using a sterile loop, remove a small amount of frozen isolate from the top of the vial

Aseptically transfer the loop to BAP

Use streak plate method to isolate single colonies

Incubate inverted plate at 35°C for 18-24 hrs.

Storage Temperature & Biosafety
STORAGE TEMPERATURE: -70°C

BIOSAFETY LEVEL: 2
Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the current publication of the BioSafety in Microbiological and Biomedical Laboratories (HHS Publication No. (CDC) 21-1112) from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Institutes of Health.

Disclaimer:
This product is sent with the condition that you are responsible for its safe storage, handling, and use. All materials are the property of the Centers for Disease Control and Prevention (CDC) and have been made available on behalf of the Food and Drug Administration (FDA). This material is not for use in human subjects and may not be redistributed. While CDC uses reasonable efforts to include accurate and up-to-date information on this product sheet, CDC makes no warranties or representations as to its accuracy. CDC is not liable for damages arising from the misidentification or misrepresentation of cultures. Please refer to the Standard Letter Agreement (SLA) for further details regarding the use of this product.
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