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Panel:   Cefepime/ zidebactam (FPZ)
AR Bank # 0610 Pseudomonas aeruginosa
Study ID: FPZ-20

Biosample Accession #: SAMN11953930

MLST: 654(Pasteur)

MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

Panel:  Cefepime/ zidebactam (FPZ)

MIC (μg/ml) Results and Interpretation
Drug MIC (μg/ml) INT
Amikacin >64R
Aztreonam >64R
Cefepime >32R
Cefepime/zidebactam 24---
Ceftazidime >128R
Ceftazidime/avibactam 1>16R
Ceftolozane/tazobactam 1>16R
Ciprofloxacin >8R
Colistin 1I
Doripenem <=0.12S
Imipenem 1S
Imipenem/relebactam 10.5---
Imipenem+chelators 31---
Levofloxacin >8R
Meropenem 0.25S
Piperacillin/tazobactam 116S
Tobramycin >16R
S – I –R Interpretation (INT) derived from CLSI 2024 M100 S34

1 Reflects MIC of first component
2 Cefepime to zidebactam ratio (1:1)
3 Screen for metallo-beta-lactamase production [Rasheed et al. Emerging Infectious Diseases. 2013. 19(6):870-878]
Device manufacturers and users of FDA cleared devices shall consult the FDA’s Antibacterial Susceptibility Test Interpretive Criteria       website for breakpoints recognized or recommended by FDA, and for information regarding FDA exceptions or additions to the applicable, recognized consensus standard.
Molecular Mechanisms of Resistance
Aminoglycoside ant(2")-la, aph(3')-Ib, aph(3')-VIa, aph(6)-Id
Beta-lactam OXA-50, VEB-1
Phenicols/Bicyclomycins bcr1
Sulfonamides sul1
Trimethoprim dfrA23
The resistance mechanisms listed were identified by analysis of whole genome sequence using the ResFinder database (last updated June 2, 2016 and accessed on October 25, 2016). This analysis does not include mutations that may result in antibiotic resistance or resistance determinants added to newer versions of the ResFinder database or other antimicrobial resistance gene databases. Biosample accession numbers have been provided so that users can analyze the data on their own if so desired.
Medium: Trypticase Soy Agar with 5% Sheep Blood (BAP)

Temperature: 35°C
Atmosphere: Aerobic

Remove the sample vial to a container with dry ice or a freezer block. Keep vial on ice or block. (Do not let vial content thaw)
Open vial aseptically to avoid contamination
Using a sterile loop, remove a small amount of frozen isolate from the top of the vial
Aseptically transfer the loop to BAP
Use streak plate method to isolate single colonies
Incubate inverted plate at 35°C ± 2°C for 18-24 hrs.
Storage Temperature & Biosafety

Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the current publication of 'BioSafety in Microbiological and Biomedical Laboratories' from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Institutes of Health.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. All materials are the property of the Centers for Disease Control and Prevention (CDC) and have been made available on behalf of the Food and Drug Administration (FDA). This material is not for use in human subjects and may not be redistributed. While CDC uses reasonable efforts to include accurate and up-to-date information on this product sheet, CDC makes no warranties or representations as to its accuracy. CDC is not liable for damages arising from the misidentification or misrepresentation of cultures. Please refer to the Standard Letter Agreement (SLA) for further details regarding the use of this product.
Isolate History
Date Action Performed
06/14/23Drug was removed: 'Gentamicin'
02/13/23MLST was updated: from '---' to '654(Pasteur)'
08/11/22Gene was added
08/11/22Category was added
08/11/22Gene was added
08/11/22Category was added
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