Skip directly to site content
Are You Still There?
Due to inactivity, you will be signed out in two minutes unless you click 'Continue'.

Panel:   Ceftolozane/tazobactam (CTV)
AR Bank # 0377 Proteus mirabilis
Study ID: CTV-27

Biosample Accession #: SAMN07291520


MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

Panel:  Ceftolozane/tazobactam (CTV)

MIC (μg/ml) Results and Interpretation
Drug MIC (μg/ml) INT
Amikacin 2S
Ampicillin >32R
Ampicillin/sulbactam 1>32R
Aztreonam <=2S
Cefazolin >8R
Cefepime 8SDD
Cefepime/zidebactam 50.12---
Cefotaxime 4R
Cefotaxime/clavulanic acid 1<=0.25---
Cefoxitin 8S
Ceftazidime 4S
Ceftazidime/avibactam 1<=0.5S
Ceftazidime/clavulanic acid 1<=0.5---
Ceftolozane/tazobactam 14I
Ceftriaxone 4R
Ciprofloxacin >8R
Colistin 4>8R
Doripenem 2I
Ertapenem 4R
Gentamicin 4I
Imipenem 16R
Imipenem+chelators 38---
Levofloxacin >8R
Meropenem 2I
Meropenem-vaborbactam 1<=0.5S
Nitrofurantoin 128R
Piperacillin/tazobactam 116S
Tetracycline >32R
Tigecycline 2 632R
Tobramycin 8R
Trimethoprim/sulfamethoxazole 1>8R
SDD (Susceptible Dose Dependent)
S – I –R Interpretation (INT) derived from CLSI 2024 M100 S34

1 Reflects MIC of first component
2 Based on FDA break points
3 Screen for metallo-beta-lactamase production [Rasheed et al. Emerging Infectious Diseases. 2013. 19(6):870-878]
4 Clinical and PK/PD data demonstrate colistin has limited clinical efficacy, even if an intermediate result is obtained. Alternative agents are strongly preferred. Colistin should be used in combination with one or more active antimicrobial agents. Consultation with an infectious disease specialist is recommended.
5 Cefepime to zidebactam ratio (1:1)
6 The interpretation of resistant is due to intrinsic resistance for this species-drug combination rather than the MIC. Refer to CLSI M100 for more information about intrinsic resistance
Device manufacturers and users of FDA cleared devices shall consult the FDA’s Antibacterial Susceptibility Test Interpretive Criteria       website for breakpoints recognized or recommended by FDA, and for information regarding FDA exceptions or additions to the applicable, recognized consensus standard.
Molecular Mechanisms of Resistance
Aminoglycoside aac(6')-Ib
Beta-lactam KPC-3, TEM-1A
Efflux pumps/Other qacEdelta1
Quinolone QnrB19
Streptothricin sat2
Sulfonamides sul1
Tetracyclines tet(J)
Trimethoprim dfrA1
Antimicrobial Resistance (AR) gene prediction was performed using a combined and deduplicated AR database (ResGANNCBI) from ARG-ANNOT, ResFinder and NCBI AMRFinder accessed on 2022-09-15. AR drug classes are assigned according to these databases. This analysis does not include mutations that may result in antimicrobial resistance, or resistance determinants added to newer versions of databases used, or other antimicrobial resistance gene databases. Additional AR genes other than those listed, may be present. For resistance determinant detection, 99-100% sequence identity and 100% sequence coverage from GAMMA and SRST2 was used. GAMMA uses amino acid sequence to assign gene alleles from assemblies; SRST2 uses nucleotide sequence to assign gene alleles from sequencing reads. Biosample accession numbers have been provided so that users can analyze the data on their own, if so desired. *MLST Type (and scheme), as determined by Torsten Seemann's MLST program. For Enterobacterales the Pasteur MLST schemes are used except for E. coli for which both the Pasteur and Achtman schemes are reported. Similarly, for Acinetobacter baumannii complex, both Pasteur and Oxford MLST schemes are used and reported. SUB=novel MLST identified and "submitted". Dash (-) indicates no pubMLST scheme is available for that species.
Medium: Trypticase Soy Agar with 5% Sheep Blood (BAP)

Temperature: 35°C
Atmosphere: Aerobic


Remove the sample vial to a container with dry ice or a freezer block. Keep vial on ice or block. (Do not let vial content thaw)

Open vial aseptically to avoid contamination

Using a sterile loop, remove a small amount of frozen isolate from the top of the vial

Aseptically transfer the loop to BAP

Use streak plate method to isolate single colonies

Incubate inverted plate at 35°C ± 2°C for 18-24 hrs.

Storage Temperature & Biosafety

Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the current publication of 'BioSafety in Microbiological and Biomedical Laboratories' from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Institutes of Health.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. All materials are the property of the Centers for Disease Control and Prevention (CDC) and have been made available on behalf of the Food and Drug Administration (FDA). This material is not for use in human subjects and may not be redistributed. While CDC uses reasonable efforts to include accurate and up-to-date information on this product sheet, CDC makes no warranties or representations as to its accuracy. CDC is not liable for damages arising from the misidentification or misrepresentation of cultures. Please refer to the Standard Letter Agreement (SLA) for further details regarding the use of this product.
Isolate History
Date Action Performed
06/06/23INT was updated with a new value for Nitrofurantoin: from '---' to 'R'
06/06/23MIC was updated with a new value for Nitrofurantoin: from '---' to '128'
06/06/23Drug was added: Nitrofurantoin
06/06/23MIC was updated with a new value for Meropenem-vaborbactam: from '---' to '<=0.5'
04/11/23INT was updated with a new value for Tobramycin: from 'I' to 'R'
04/11/23INT was updated with a new value for Gentamicin: from 'S' to 'I'
12/07/22MIC was updated with a new value for Cefepime/zidebactam: from '---' to '0.12'
12/07/22Drug was added: Cefepime/zidebactam
Top of Page