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Panel:   Neisseria gonorrhoeae Surveillance 2021 (GSUV)
AR Bank # 1262 Neisseria gonorrhoeae
Study ID: GSUV-99

Biosample Accession #: SAMN27178333

   

Collection Year: 2021
Location: USA
Source: Urethra

MIC results provided were determined by agar dilution.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

Panel:  Neisseria gonorrhoeae Surveillance 2021 (GSUV)


MIC (μg/ml) Results and Interpretation
Drug MIC (μg/ml) INT
Aztreonam 0.125S
Cefixime 0.03S
Ceftriaxone 0.015S
Ciprofloxacin 0.004S
Gentamicin 8---
Penicillin 0.5I
Tetracycline 1I
Device manufacturers and users of FDA cleared devices shall consult the FDA’s Antibacterial Susceptibility Test Interpretive Criteria       website for breakpoints recognized or recommended by FDA, and for information regarding FDA exceptions or additions to the applicable, recognized consensus standard.
Molecular Mechanisms of Resistance
CategoryGene
 
Disclaimer:

The resistance mechanisms listed were identified by analysis of whole genome sequence using the ResFinder database (last updated June 2, 2016 and accessed on October 25, 2016). This analysis does not include mutations that may result in antibiotic resistance or resistance determinants added to newer versions of the ResFinder database or other antimicrobial resistance gene databases. Biosample accession numbers have been provided so that users can analyze the data on their own if so desired.
Propagation
MEDIUM
Medium: GC agar base and 1% defined growth supplement and/or 1% hemoglobin

GROWTH CONDITIONS
Temperature: 36°C
Atmosphere: 5% CO₂

PROPAGATION PROCEDURE

Remove the sample vial to a container with dry ice or a freezer block. Keep vial on ice or block. (Do not let vial content thaw)

Open vial aseptically to avoid contamination

Using a sterile loop, remove a small amount of frozen isolate from the top of the vial

Aseptically transfer the loop to GC agar

Use streak plate method to isolate single colonies

Incubate inverted plate at 36°C ± 1°C in 5% CO₂ for 20-24 hrs.
Storage Temperature & Biosafety
STORAGE TEMPERATURE: -70°C

BIOSAFETY LEVEL: 2

Appropriate safety procedures should always be used with this material. Laboratory safety is discussed in the current publication of 'BioSafety in Microbiological and Biomedical Laboratories' from the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, and National Institutes of Health.



Disclaimer:

This product is sent with the condition that you are responsible for its safe storage, handling, and use. All materials are the property of the Centers for Disease Control and Prevention (CDC) and have been made available on behalf of the Food and Drug Administration (FDA). This material is not for use in human subjects and may not be redistributed. While CDC uses reasonable efforts to include accurate and up-to-date information on this product sheet, CDC makes no warranties or representations as to its accuracy. CDC is not liable for damages arising from the misidentification or misrepresentation of cultures. Please refer to the Standard Letter Agreement (SLA) for further details regarding the use of this product.
Isolate History
Date Action Performed
05/25/23Source was changed: from '---' to 'Urethra'
04/03/23Isolate Status changed: from 'Pending' to 'Active'
10/25/22Sequence Accession # changed
10/25/22INT was updated with a new value for Tetracycline: from '---' to 'I'
10/25/22INT was updated with a new value for Penicillin: from '---' to 'I'
10/25/22INT was updated with a new value for Gentamicin: from '---' to '---'
10/25/22INT was updated with a new value for Ciprofloxacin: from '---' to 'S'
10/25/22INT was updated with a new value for Ceftriaxone: from '---' to 'S'
10/25/22INT was updated with a new value for Cefixime: from '---' to 'S'
10/25/22INT was updated with a new value for Aztreonam: from '---' to 'S'
10/25/22MIC was updated with a new value for Tetracycline: from '---' to '1'
10/25/22MIC was updated with a new value for Penicillin: from '---' to '0.5'
10/25/22MIC was updated with a new value for Gentamicin: from '---' to '8'
10/25/22MIC was updated with a new value for Ciprofloxacin: from '---' to '0.004'
10/25/22MIC was updated with a new value for Ceftriaxone: from '---' to '0.015'
10/25/22MIC was updated with a new value for Cefixime: from '---' to '0.03'
10/25/22MIC was updated with a new value for Aztreonam: from '---' to '0.125'
10/25/22Drug was added: Aztreonam
10/25/22Drug was added: Ciprofloxacin
10/25/22Drug was added: Ceftriaxone
10/25/22Drug was added: Cefixime
10/25/22Drug was added: Gentamicin
10/25/22Drug was added: Tetracycline
10/25/22Drug was added: Penicillin
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