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Cefepime/ zidebactam (FPZ)

A panel of gram-negative bacteria with varying susceptibilities to cefepime/zidebactam. This panel can be used for “in-house” validation of cefepime/zidebactam antimicrobial susceptibility testing methods. Isolates were selected to represent a diversity of species and resistance mechanisms including carbapenemases. Cefepime/zidebactam MICs reflect MIC of the combination.
Panel ID: FPZ

MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

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AR Bank #	Organism	Resistance Mechanisms	Biosample Accession #
0591	Escherichia coli	aadA1, ant(2")-la, cmlA6, CTX-M-15, mph(A), qepA1, rmtB, sul1, tet(B)	SAMN11953911
0592	Escherichia coli	aph(6)-Id, ARR-2, CMY-4, dfrA14, ere(A), mph(A), OXA-9, SHV-12, strA, sul2, TEM-1B	SAMN11953912
0593	Escherichia coli	CMY-6, CTX-M-15	SAMN11953913
0594	Escherichia coli	aac(3)-IIa, aac(6')-Ib-cr, aadA5, aph(6)-Id, catB4, CMY-42, CTX-M-15, dfrA17, mph(A), OXA-1, sul1, sul2, tet(B)	SAMN11953914
0595	Escherichia coli	aac(3)-IIa, aac(6')-Ib-cr, aadA5, catB4, CTX-M-15, dfrA1, dfrA17, DHA-1, mph(A), OXA-1, QnrB4, sul1, tet(B)	SAMN11953915
0596	Escherichia coli	aadA5, CMY-42, CTX-M-15, dfrA17, mph(A), sul1, TEM-1B, tet(B)	SAMN11953916
0597	Escherichia coli	aac(3)-IIa, aac(6')-Ib-cr, catB4, CMY-42, CTX-M-15, mph(A), OXA-1, tet(A), tet(R)	SAMN11953917
0598	Escherichia coli	aac(3)-IIa, aac(6')-Ib-cr, aadA1, ant(2")-la, catB4, cmlA6, CTX-M-15, dfrA14, dfrA24, NDM-1, OXA-1, qepA1, QnrB1, rmtB, sul1, TEM-1B, tet(B)	SAMN11953918
0599	Klebsiella pneumoniae	aac(6')-Ib, aadA1, aph(3')-VI, CTX-M-15, NDM-1, OXA-9, QnrS1, SHV-100, SHV-28, TEM-1B	SAMN11953919
0600	Klebsiella pneumoniae	aadA2, ARR-2, CTX-M-15, dfrA12, mph(A), QnrS1, rmtF, SHV-12, sul1, TEM-1B	SAMN11953920
0601	Klebsiella pneumoniae	aac(3)-IIa, CTX-M-2, OXA-2, SHV-1, sul1, TEM-1B	SAMN11953921
0602	Klebsiella pneumoniae	aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, catB4, CTX-M-15, dfrA14, fosA, OXA-1, QnrB1, SHV-1, sul2	SAMN11953922
0603	Klebsiella pneumoniae	aph(6)-Id, CTX-M-15, dfrA14, SHV-11, sul2, TEM-1A, tet(D)	SAMN11953923
0604	Klebsiella pneumoniae	aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, armA, CMY-23, CTX-M-15, dfrA12, LAP-2, mph(A), mph(E), msr(E), oqxA, oqxB, OXA-9, QnrS1, SHV-11, sul1, TEM-1B, tet(D)	SAMN11953924
0605	Klebsiella pneumoniae	aac(3)-IIa, aadA1, CTX-M-2, OXA-2, SHV-187, sul1, TEM-1B	SAMN11953925
0606	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, catB4, CTX-M-15, dfrA14, KPC-2, OXA-1, QnrB1, SHV-99, sul2, TEM-1B, tet(A), tet(R)	SAMN11953926
0607	Enterobacter cloacae	aac(6')-IIc, aadA2, ACT-16, aph(6)-Id, armA, CTX-M-15, dfrA12, ere(A), mph(E), msr(E), strA, sul1, sul2, TEM-1B	SAMN11953927
0608	Serratia marcescens	ant(2")-la, aphA16, SHV-105, SRT-2	SAMN11953928
0609	Pseudomonas aeruginosa	aac(3)-Ic, aac(6')-IB3, cmlA5, sul1, VEB-5	SAMN11953929
0610	Pseudomonas aeruginosa	ant(2")-la, aph(3')-Ib, aph(3')-VIa, aph(6)-Id, bcr1, dfrA23, OXA-50, sul1, VEB-1	SAMN11953930
0611	Pseudomonas aeruginosa	aph(3')-Ib, aph(6)-Id, OXA-50, rmtB4, sul1, tet(G), VIM-11	SAMN11953931
0612	Escherichia coli	aph(3')-VI, NDM-7, QnrB1, rmtC, sul1	SAMN11953932
0614	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aadA2, armA, catB4, CMY-4, CTX-M-15, dfrA12, mph(E), msr(E), OXA-1, OXA-181, QnrB1, SHV-1, sul1, TEM-1B, tet(D)	SAMN11953934
0615	Klebsiella pneumoniae	aadA2, aph(3')-Ib, aph(6)-Id, armA, CMY-4, CTX-M-15, dfrA12, mph(E), msr(E), OXA-181, QnrB1, SHV-1, sul1, sul2	SAMN11953935
0616	Escherichia coli	aadA2, CMY-42, dfrA12, NDM-5, rmtB, sul1, TEM-1B	SAMN11953936

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CDC & FDA Antimicrobial Resistance Isolate Bank

Cefepime/ zidebactam (FPZ)

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