The panel consists of 20 isolates with a selection of mutations in the resistance determinants for CIP, gyrA and parC. It is designed for diagnostic test developers to test gene specific tests for ciprofloxacin resistance/susceptibility based on these genes.
We have received reports of discrepant sequencing results between what is obtained from the AR Isolate Bank for AR-0975 Neisseria gonorrhoeae and the information available from the National Center for Biotechnology Information (NCBI). We at CDC, have been and are continuing to investigate the source of this discrepancy to correct it. In the meantime, we are removing this isolate from the NCIP panel.
We apologize for any inconvenience this might create.
Panel ID: NCIP
MIC results provided were determined by agar dilution.
MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).
Characterization of a Neisseria gonorrhoeae Ciprofloxacin panel for an antimicrobial resistant Isolate Bank (plos.org)
