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Enterobacterales Carbapenem Breakpoint (BIT)

This panel was assembled to challenge tests that assess carbapenem susceptibility of Enterobacterales. Isolates in this collection demonstrate a range of carbapenem susceptibility. The carbapenem-resistant isolates also have different resistance mechanisms (i.e., some isolates produce a carbapenemase and others do not).
Panel ID: BIT

MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

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AR Bank #	Organism	Resistance Mechanisms	Biosample Accession #
0001	Escherichia coli	aac(6')-Ib-cr, aadA5, ACRF, catB4, dfrA17, KPC-3, MDF(A), mph(A), OXA-1, sul1, tet(A), tet(R)	SAMN04014842
0002	Enterobacter cloacae	aac(6')-Ib, aadA1, ACT-45, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, dfrA14, KPC-3, OmpF2, OXA-9, sul2, TEM-1A	SAMN04014843
0003	Klebsiella pneumoniae	aac(6')-Ib, aadA1, aph(3')-Ib, aph(6)-Id, dfrA14, EMRD, KDEA, KPC-3, Omp35, OmpK35, oqxA, oqxB, OXA-9, SHV-12, sul2, TEM-1A	SAMN04014844
0004	Klebsiella pneumoniae	aac(6')-Ib, aadA1, aadA2, catA1, dfrA12, EMRD, KDEA, KPC-3, Omp35, OmpK35, oqxB, OXA-9, SHV-11, sul1, TEM-1A	SAMN04014845
0005	Klebsiella pneumoniae	aac(6')-Ib, aph(3')-Ia, catA1, dfrA12, EMRD, KDEA, KPC-2, mph(A), Omp35, OmpK35, oqxA, oqxB, OXA-9, SHV-11, sul1, TEM-1A	SAMN04014846
0006	Escherichia coli	aac(3)-IIa, aac(6')-IB3, aadA5, ACRF, aph(3')-Ib, aph(6)-Id, cmlA1, CMY-2, CTX-M-14, dfrA17, EMRD, MDF(A), mph(A), OmpC, OmpC2, OmpF, sul1, sul2, TEM-1, tet(A)	SAMN04014847
0007	Klebsiella aerogenes		SAMN04014848
0008	Enterobacter cloacae	ACT-15, Omp36, OmpC, OmpC2, OmpF2, OmpK36	SAMN04014849
0009	Klebsiella aerogenes	CMY2-MIR-ACT-EC, Omp35, Omp36, OmpK35, OmpK36	SAMN04014850
0010	Klebsiella pneumoniae	CMY-94, EMRD, fosA, KDEA, Omp35, OmpK35, oqxA, oqxB14, SHV-1	SAMN04014851
0011	Escherichia coli	aac(3)-IIa, aac(6')-Ib-cr, ACRF, aph(6)-Id, catB4, CTX-M-15, dfrA4, EMRD, MDF(A), OXA-1, strA, sul2, tet(A), tet(R)	SAMN04014852
0012	Klebsiella pneumoniae	aac(3)-Iva, aac(6')-Ib, aadA1, aph(4)-Ia, catA1, cmlA1, dfrA12, EMRD, KDEA, Omp35, OmpK35, oqxA, oqxB, SHV-12, sul1, sul3	SAMN04014853
0013	Escherichia coli	aac(3)-IId, aadA2, catA1, CTX-M-14, dfrA12, EC-5, EMRD, MDF(A), mph(A), sul1, TEM-1, tet(A), tet(R)	SAMN04014854
0014	Escherichia coli	aac(3)-IIa, aac(6')-Ib-cr, ACRF, catB4, CTX-M-15, EMRD, MDF(A), OXA-1, tet(A), tet(R)	SAMN04014855
0015	Escherichia coli	aac(3)-IId, aac(6')-Ib-cr, aadA5, ACRF, aph(3')-Ib, aph(6)-Id, catB4, CTX-M-15, dfrA17, EMRD, MDF(A), mph(A), OmpF, OXA-1, sul1, sul2, TEM-1, tet(A), tet(B), tet(R)	SAMN04014856
0016	Klebsiella pneumoniae	KDEA, LEN-27, oqxA, oqxB9	SAMN04014857
0017	Escherichia coli	ACRF, EMRD, MDF(A)	SAMN04014858
0018	Klebsiella aerogenes		SAMN04014859
0019	Escherichia coli	ACRF, EC-13, EMRD, MDF(A), TEM-1	SAMN04014860
0020	Escherichia coli	ACRF, MDF(A)	SAMN04014861
0021	Citrobacter freundii	CMY-108, QnrB13	SAMN04014862
0022	Citrobacter freundii	CMY-109, QnrB38	SAMN04014863
0023	Citrobacter freundii	CMY-108, QnrB13	SAMN04014864
0024	Citrobacter koseri	MAL-1	SAMN04014865
0025	Citrobacter koseri	aac(3)-IId, aadA2, aph(6)-Id, dfrA12, MAL-1, mph(A), strA, sul1, sul2, TEM-1, tet(A), tet(R)	SAMN04014866

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CDC & FDA Antimicrobial Resistance Isolate Bank

Enterobacterales Carbapenem Breakpoint (BIT)

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