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Gram Negative Carbapenemase Detection (CarbaNP)

This panel was assembled to challenge assays that detect carbapenemase production. Isolates in this collection represent a range of gram-negative bacteria; some producing a carbapenemase and others that demonstrate reduced susceptibility to carbapenems, but do not produce a carbapenemase. This collection was assembled to challenge assays that detect carbapenemase production.
Panel ID: CarbaNP

MICs obtained by broth microdilution. Modal MIC is reported.

MIC results for each antimicrobial agent for an isolate may commonly be ± 1 log2 (doubling dilution) different than what is posted on the FDA & CDC AR Bank website because this is the normal technical variability of antimicrobial susceptibility testing (see J. H. Jorgensen. 1993. J Clin Microbiol. Vol 31[11]: 2841-2844).

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AR Bank #	Organism	Resistance Mechanisms	Biosample Accession #
0032	Enterobacter cloacae	aac(3)-IIg, aac(6')-IIc, ACT-16, aph(3')-Ia, aph(6)-Id, ARR-2B, catA2, dfrA19, KPC-3, mcr-9.1, qacEdelta1, QnrB2, strA, sul1, sul2, TEM-1	SAMN04014873
0033	Acinetobacter baumannii	ABAF, ant(3")-IIa, ble-MBL, NDM-1, OXA-94, sul2	SAMN04014874
0034	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib-G, catB3, EMRD, IMP-4, KDEA, mph(A), oqxA, oqxB25, qacEdelta1, qacG2, QnrB2, SHV-11, sul1, TEM-1	SAMN04014875
0035	Acinetobacter baumannii	ABAF, ADC-30, ADEC, aph(3')-Ia, aph(6)-Id, mph(E), msr(E), OXA-66, OXA-72, strA, sul2, TEM-1D, tet(B)	SAMN04014876
0036	Acinetobacter baumannii	aac(6')-Ian, ABAF, ADC-214, ant(3")-IIa, aph(6)-Id, OXA-24, OXA-65, strA, sul2	SAMN04014877
0037	Acinetobacter baumannii	ABAF, ADC-80, ant(2")-la, ant(3")-IIa, aph(3')-VI, ble-MBL, NDM-1, OXA-94, sul2	SAMN04014878
0038	Enterobacter cloacae	aac(3)-IId, aac(6')-Ib, aadA1, aadA2, ACT-17, armA, ble-MBL, catB4, CTX-M-15, dfrA12, floR2, fosA, LAP-2, mph(E), msr(E), NDM-1, Omp36, OmpC, OmpC2, OmpK36, OXA-1, OXA-9, qacEdelta1, QnrS1, rmtB4, sul1, TEM-1, tet(G)	SAMN04014879
0039	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib-cr, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, ARR-2, catA1, CTX-M-15, dfrA12, dfrA14, EMRD, ere(A), fosA5, KDEA, Omp35, OmpK35, oqxB9, oqxB9, OXA-181, qacEdelta1, SHV-26, sul1, sul2, tet(A), tet(R)	SAMN04014880
0040	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aac(6')-Il, aph(3')-Ia, aph(6)-Id, catB4, CTX-M-15, dfrA1, EMRD, KDEA, mph(A), Omp35, OmpK35, oqxA, oqxB25, OXA-1, qacEdelta1, SHV-11, strA, sul1, tet(A), tet(R), VIM-27	SAMN04014881
0041	Klebsiella pneumoniae	aac(6')-IIa, aadA1, aph(3")-Ib, aph(3')-VI, aph(6)-Id, armA, ARR-2, ble-MBL, catB11, cmlA5, CMY-4, CTX-M-15, dfrA1, EMRD, fosA5, KDEA, mph(E), msr(E), NDM-1, oqxA, oqxB, OXA-10, qacEdelta1, SHV-11, sul1, sul2, tet(A), tet(R)	SAMN04014882
0042	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aadA1, aadA5, aph(3')-Ia, ARR-2, catA2, catB4, cmlA5, CTX-M-15, dfrA14, dfrA17, EMRD, erm(42), floR, fosA10, KDEA, mph(A), oqxA10, oqxB19, OXA-1, OXA-10, qacEdelta1, QnrS1, SHV-1, sul1, sul2, TEM-1	SAMN04014883
0043	Klebsiella pneumoniae	EMRD, KDEA, oqxA, oqxB32, SHV-12	SAMN04014884
0044	Klebsiella pneumoniae	aac(3)-IId, aac(6')-Ib, aadA1, catA1, catB4, CTX-M-15, dfrA14, EMRD, floR, fosA5, KDEA, Omp35, OmpK35, oqxA, oqxB25, OXA-1, OXA-9, SHV-11, sul2, TEM-1A	SAMN04014885
0045	Acinetobacter baumannii	A1, A2, aac(3)-Ia, aadA1, ABAF, ADC-11, AMVA, ant(3")-IIa, aph(3')-Ia, catA1, OXA-23, OXA-69, qacEdelta1, sul1, TEM-1D, tet(A), tet(R)	SAMN04014886
0046	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-cr, aac(6')-Il, aph(3')-Ia, aph(6)-Id, catB4, CTX-M-15, dfrA1, EMRD, KDEA, mph(A), Omp35, OmpK35, oqxA, oqxB25, OXA-1, qacEdelta1, SHV-11, strA, sul1, tet(A), tet(R), VIM-27	SAMN04014887
0047	Klebsiella pneumoniae	aac(6')-Ib, aadA2, catA1, dfrA12, EMRD, KDEA, mph(A), Omp35, OmpK35, oqxA, oqxB, qacEdelta1, sul1, TEM-1A, tet(D)	SAMN04014888
0048	Escherichia coli	aac(6')-IB3, aadA2, ACRF, aph(3')-Ia, aph(6)-Id, ble-MBL, catA1, CMY-6, CTX-M-15, dfrA12, dfrA29, dfrA4, EMRD, NDM-1, OmpF, OXA-2, qacEdelta1, rmtC, strA, sul1, TEM-1, tet(B)	SAMN04014889
0049	Klebsiella pneumoniae	aac(3)-IIa, aac(6')-Ib-D181Y, aadA2, aph(3')-Ib, aph(6)-Id, ble-MBL, catB4, CMY-6, CTX-M-15, dfrA14, EMRD, KDEA, mph(A), NDM-1, Omp35, OmpK35, oqxA, oqxB, OXA-1, qacEdelta1, QnrB9, rmtC, SHV-53, sul1, sul2, TEM-1, tet(A), tet(R)	SAMN04014890
0050	Enterobacter cloacae	aac(3)-Ib, ACT-24, aph(3')-Ia, dfrA14, dfrA15, KPC-4, LAP-2, qacEdelta1, qacF, QnrS1, sul1, TEM-1A	SAMN04014891
0051	Klebsiella ozaenae	aac(3)-IId, aac(6')-Ib-cr, aadA1, aadA2, armA, ARR-2, catA1, CTX-M-15, dfrA12, dfrA14, EMRD, ere(A), fosA5, KDEA, Omp35, OmpK35, OXA-181, qacEdelta1, SHV-26, sul1, sul2, tet(A), tet(R)	SAMN04014892
0052	Acinetobacter baumannii	ABAF, ADC-79, ant(3")-IIa, OXA-100, OXA-58, sul2	SAMN04014893
0053	Enterobacter cloacae	aac(6')-Ib, aadA1, ACT-45, aph(3")-Ib, aph(3')-Ia, aph(6)-Id, dfrA14, KPC-3, OmpF2, OXA-9, sul2, TEM-1A	SAMN04014894
0054	Pseudomonas aeruginosa	ant(2")-la, aph(3')-IIb, aph(6)-Id, bcr1, bcr1, bcr1, catB7, fosA, mexA, mexE, mexX, OXA-396, PDC-3, sul1, sul1, sul1, tet(A), tet(R), tet(R), tet(R), VIM-4	SAMN04014895
0055	Escherichia coli	aac(3)-IIa, aac(6')-Ib-D181Y, aadA5, ACRF, ble-MBL, catB4, CMY-6, dfrA17, mph(A), NDM-1, OXA-1, qacEdelta1, rmtC, sul1, tet(A), tet(R)	SAMN04014896
0056	Acinetobacter baumannii	aac(3)-IIe, ABAF, ADC-212, ADEC, aph(3')-Ia, aph(6)-Id, mph(E), msr(E), OXA-23, OXA-66, strA, sul2, tet(B)	SAMN04014897

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CDC & FDA Antimicrobial Resistance Isolate Bank

Gram Negative Carbapenemase Detection (CarbaNP)

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