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Virus Name: Sagiyama

Abbreviation: SAGV

Status
Probable Arbovirus

Select Agent
No

SALS Level
3

SALS Basis
Disease is sheep, cattle, or horses.

Other Information

Antigenic Group
A

Section VIII - Susceptibility to Experimental Infection (include viremia)

Experimental host and age	Passage history and strain	Inoculation Route-Dose	Evidence of infection	AST (days)	Titer log10/ml


Titer of virus from suckling mouse muscle approximately = that from brain.
Host range: No overt disease in adult rabbits (inoculated ip) or in guinea pigs (weanlings inoculated ic and ip, and adults inoculated ip). Chicks develop viremia 2-4 days after sc and two days after iv inoculation of low mouse passage virus. Liver and spleen (pooled) and brain of baby chicks, dying 2 days after iv inoculation yielded virus. No regular deaths or signs of illness in chicks occurred after sc inoculation. In embryonated chicken eggs, certain strains produce death and hemorrhage in embryos upon inoculation by CAM or yolk sac routes. Virus has been passed by yolk sac inoculation and harvest of embryos through 15 passages. However, titers for embryonated chicken eggs remain low.

Mice (nb)	SM 15	ic 0.01	CNS signs or paralysis	2-7	9.5-10.5
Mice (nb)		ip 0.01	CNS signs or paralysis	4-10
Mice (nb)		sc
Mice (wn)	SM 8	ic 0.03	None
Mice (wn)		ip

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