Prevention Research Synthesis (PRS) HIV Compendium of Best Practices

ChiCAS (Chicas Creando Acceso a la Salud or Girls Creating Access to Health) is a Spanish-language, group- and empowerment-based intervention that aims to increase use of PrEP, condoms, and medically supervised gender-affirming hormone therapy. The participants develop skills to seek and obtain PrEP and hormone therapy from a medical provider within the community.

Rhodes, S. D., Alonzo, J., Mann-Jackson, L., Aviles, L. R., Tanner, A. E., Galindo, C. A., Bessler, P. A., Courtenay-Quirk, C., Garcia, M., Sucaldito, A. D., Smart, B. D., Goldenberg, T., & Reboussin, B. A. (2024). PrEP uptake among Spanish-speaking transgender women: A randomized controlled trial in North and South Carolina, 2019-2022. American Journal of Public Health, 114(1), 68-78. doi: 10.2105/AJPH.2023.307444

PrEPTECH is an electronic health (eHealth) intervention delivered over the course of 6 months. The intervention provides PrEP information, free home test kits for HIV/Hepatitis B/sexually transmitted infections, and (if indicated) a free 1- or 6-month supply of PrEP that is mailed by a mail order pharmacy. Custom text and email-based adherence reminders are offered. Assistance on how to obtain PrEP after the intervention period is also provided.

Erenrich, R. K., Braun, R. A., Torres-Mendoza, D. M., Stevenson, O. L., Doan, T. P., & Klausner, J. D. (2024). Effectiveness of PrEPTECH: Findings from a 180-day randomized controlled trial of a pre-exposure prophylaxis telehealth intervention. JAIDS Journal of Acquired Immune Deficiency Syndromes, 95(5), 463-469. doi: 10.1097/QAI.0000000000003375

2GETHER teaches couples to use relationship skills to improve relational functioning and sexual health via a telehealth delivery model. The intervention includes the following three videoconferencing group sessions led by two trained facilitators aimed at building skills. Before each session, participants view self-paced video modules that address communication skills, coping with stress, relationship satisfaction, and HIV transmission.

Newcomb, M. E., Swann, G., Macapagal, K., Sarno, E. L., Whitton, S. W., & Mustanski, B. (2023). Biomedical and behavioral outcomes of 2GETHER: A randomized controlled trial of a telehealth HIV prevention program for young male couples. Journal of Consulting and Clinical Psychology, 91(9), 505-520. doi: 10.1037/ccp0000823

E-VOLUTION is a mobile health (mHealth) intervention with a human support element. The intervention aims to improve assistance overcoming barriers to improve health outcomes with automated two-way messaging and live text messages between medical case managers and participants.

Gerke, D. R., Glotfelty, J., Slovacek, S., Freshman, M., Schlueter, J., & Plax, K. (2023). More than just reminders: Using text messaging to improve HIV care outcomes among youth and young adults living with HIV. AIDS and Behavior, 27(9), 2988–2996. doi.org/10.1007/s10461-023-04022-2

HIV PrEP Services for Urban Women is a multicomponent, educational HIV PrEP intervention that promotes universal PrEP services for cisgender women attending sexual and reproductive health centers.

Scott, R. K., Deyarmond, M., Marwitz, S., Huang, J. C., Moriarty, P., Visconti, A. J., Beverley, J., Elion, R., Coleman, M., & Hull, S. J. (2023). Implementation of an educational intervention to improve HIV pre-exposure prophylaxis services for women in an urban sexual health clinic. AIDS Patient Care and STDs, 37(9), 447-457. doi: 10.1089/apc.2023.0107

RISE uses a trained peer counselor to conduct motivational interviewing (MI) with Black or African American PWH to address self-identified barriers to taking ART. The peer counselor also links PWH to services for unmet basic needs and encourages engagement with sources of resilience in Black or African American communities.

Bogart, L. M., Mutchler, M. G., Goggin, K., Ghosh-Dastidar, M., Klein, D. J., Saya, U., Linnemayr, S., Lawrence, S. J., Tyagi, K., Thomas, D., Gizaw, M., Bailey, J., & Wagner, G. J. (2023). Randomized controlled trial of Rise, a community-based culturally congruent counseling intervention to support antiretroviral therapy adherence among Black/African American adults living with HIV. AIDS and Behavior, 27(5), 1573-1586. doi: 10.1007/s10461-022-03921-0

Suppression Bundle consists of three to five evidence-informed bundled strategies tailored to individual patients that aim to improve HIV viral suppression in persons with HIV at an outpatient infectious disease clinic setting. The Suppression Bundle addresses food insecurity, transportation, substance use, mental health, and HIV medication adherence.

Poplin, V., Katz, J., Herrman, M., Robertson, K., Chen, G., Clough, L. A. & Newman, J. R. (2023). Effectiveness of a “Suppression Bundle” to improve HIV virologic suppression in an outpatient infectious disease clinic: A pilot implementation study. AIDS Care, 35(7), 1064-1068. doi: 10.1080/09540121.2022.2040720

The Alexis Project utilizes social network recruitment, peer health navigation, and contingency management to increase HIV testing and engagement in HIV care for transgender women of color living with HIV.

Rebchook, G. M., Chakravarty, D., Xavier, J. M., Keatley, J. G., Maiorana, A., Sevelius, J., Shade, S. B., & the SPNS Transgender Women of Color Study Group. (2022). An evaluation of nine culturally tailored interventions designed to enhance engagement in HIV care among transgender women of colour in the United States. Journal of the International AIDS Society, 25(Suppl. 5), e25991. https://doi.org/ 10.1002/jia2.25991

The Brandy Martell Project aims to engage and retain adult transgender women of color into HIV care. The intervention was implemented in a gender-affirming care clinic and sought to address structural barriers to HIV care engagement and retention. Major intervention aspects include outreach, individual and full risk-reduction counseling services, agency- and venue-based screening for HIV and other sexual transmitted infections, one-time and multi-session educational groups, and legal assistance.

Rebchook, G. M., Chakravarty, D., Xavier, J. M., Keatley, J. G., Maiorana, A., Sevelius, J., Shade, S. B., & the SPNS Transgender Women of Color Study Group. (2022). An evaluation of nine culturally tailored interventions designed to enhance engagement in HIV care among transgender women of colour in the United States. Journal of the International AIDS Society, 25(Suppl. 5), e25991. https://doi.org/ 10.1002/jia2.25991

Electronic Health Record (EHR) Alert for HIV Screening uses an electronic health record algorithm that identifies patients in an urban emergency department (ED) who meet specific criteria for HIV screening, as defined by the United States Preventive Services Tasks Force (USPSTF). Triage nurses receive the alert, obtain consent from the patient, and place an order for the screening.

Bitter, C. C., Parmentier, M., Subramaniam, D. S., Byrne, L., & Buchanan, P. (2022). An electronic health record alert increases human immunodeficiency virus screening and case identification in a high-risk emergency department population. International Journal of STD & AIDS, 33(7), 722-725. doi: 10.1177/09564624221096001.