

2GETHER teaches couples to use relationship skills to improve relational functioning and sexual health via a telehealth delivery model. The intervention includes the following three videoconferencing group sessions led by two trained facilitators aimed at building skills. Before each session, participants view self-paced video modules that address communication skills, coping with stress, relationship satisfaction, and HIV transmission.
Intended population: Young male couples
Key intervention effects: Decreased condomless anal sex, Decreased number of condomless anal sex partners, Decreased sexually transmitted infections (STIs)
Location: None reported
Study Years: 2018 – 2020
Structural components: None reported
EHE pillar: None
Newcomb, M. E., Swann, G., Macapagal, K., Sarno, E. L., Whitton, S. W., & Mustanski, B. (2023). Biomedical and behavioral outcomes of 2GETHER: A randomized controlled trial of a telehealth HIV prevention program for young male couples. Journal of Consulting and Clinical Psychology, 91(9), 505-520. doi: 10.1037/ccp0000823
E-VOLUTION is a mobile health (mHealth) intervention with a human support element. The intervention aims to improve assistance overcoming barriers to improve health outcomes with automated two-way messaging and live text messages between medical case managers and participants.
Intended population: Youth and young adults with HIV
Key intervention effects: Improved retention in HIV care, Improved HIV viral suppression
Location: St. Louis, MO (HIV clinic sites at Washington University School of Medicine)
Study years: 2017 – 2019
Structural components: None reported
EHE pillar: Treat
Gerke, D. R., Glotfelty, J., Slovacek, S., Freshman, M., Schlueter, J., & Plax, K. (2023). More than just reminders: Using text messaging to improve HIV care outcomes among youth and young adults living with HIV. AIDS and Behavior, 27(9), 2988–2996. doi.org/10.1007/s10461-023-04022-2
Extension for Community Health Care Outcomes Model PrEP Curriculum (Project ECHO) is an intervention that provides a virtual program to PrEP prescribers in primary and women’s healthcare clinics. The intervention is delivered to providers in sessions using clinical integration models built on existing STI management workflows aimed at increasing the numbers of PrEP prescribers and the volume of PrEP prescriptions.
Intended population: Clinic providers
Key intervention effects: Increase in providers prescribing PrEP; Increase in PrEP use
Location: New York, New York (primary care and women’s health clinics)
Study years: 2018 – 2021
Structural components: Access, Capacity Building, Physical Structure, Policy/Procedure, Social Determinants of Health
EHE pillars: Prevent


Casey, E., Kaplan-Lewis, E., Gala, K., & Lakew, R. (2023). Successful integration of HIV PrEP in primary care and women's health clinical practice: A model for implementation. Viruses, 15, 1365. doi.org/10.3390/v15061365
HIV PrEP Services for Urban Women is a multicomponent, educational HIV PrEP intervention that promotes universal PrEP services for women attending sexual and reproductive health centers.
Intended population: Healthcare providers in an urban sexual health clinic
Key intervention effects: Increased PrEP prescription/initiation for female clinic patients, Increased PrEP persistence for female clinic patients
Location: Washington, DC (sexual health clinic)
Study years: 2018 – 2019
Structural components: Access, Capacity Building, Policy/Procedure
EHE pillar: Prevent


Scott, R. K., Deyarmond, M., Marwitz, S., Huang, J. C., Moriarty, P., Visconti, A. J., Beverley, J., Elion, R., Coleman, M., & Hull, S. J. (2023). Implementation of an educational intervention to improve HIV pre-exposure prophylaxis services for women in an urban sexual health clinic. AIDS Patient Care and STDs, 37(9), 447-457. doi: 10.1089/apc.2023.0107
RISE uses a trained peer counselor to conduct motivational interviewing (MI) with Black or African American PWH to address self-identified barriers to taking ART. The peer counselor also links PWH to services for unmet basic needs and encourages engagement with sources of resilience in Black or African American communities.
Intended population: Black or African American persons with HIV (PWH) on antiretroviral therapy (ART) but not yet virally suppressed and/or non-adherent to ART
Key intervention effects: Improved ART adherence
Location: Los Angeles, CA (community-based HIV services organization)
Study years: 2018 – 2021
Structural components: Social Determinants of Health
EHE pillar: Treat


Bogart, L. M., Mutchler, M. G., Goggin, K., Ghosh-Dastidar, M., Klein, D. J., Saya, U., Linnemayr, S., Lawrence, S. J., Tyagi, K., Thomas, D., Gizaw, M., Bailey, J., & Wagner, G. J. (2023). Randomized controlled trial of Rise, a community-based culturally congruent counseling intervention to support antiretroviral therapy adherence among Black/African American adults living with HIV. AIDS and Behavior, 27(5), 1573-1586. doi: 10.1007/s10461-022-03921-0
SMART Sex Ed is the first component of SMART, a stepped care package of eHealth interventions that addresses the sexual and HIV prevention needs of AMSM. SMART Sex Ed contains four modules that participants navigate in any order they choose. SMART Sex Ed is delivered in English or Spanish depending on participant preference.
Intended population: English and Spanish speaking adolescent men who have sex with men (AMSM), who are 13-18 years old and do not have HIV
Key intervention effects: Increased PrEP use
Location: United States and territories (online URL)
Study years: 2018 – 2020
Structural components: None reported
EHE pillar: Prevent

Mustanski, B., Saber, R., Macapagal, K., Matson, M., Laber, E., Rodriguez-Diaz, C., Moran, K. O., Carrion, A., Moskowitz, D. A., & Newcomb, M. E. (2023). Effectiveness of the SMART Sex Ed program among 13-18 year old English and Spanish speaking adolescent men who have sex with men. AIDS and Behavior, 27(2), 733-744. doi: 10.1007/s10461-022-03806-2
Suppression Bundle consists of three to five evidence-informed bundled strategies tailored to individual patients that aim to improve HIV viral suppression in persons with HIV at an outpatient infectious disease clinic setting. The Suppression Bundle addresses food insecurity, transportation, substance use, mental health, and HIV medication adherence.
Intended population: Patients at HIV clinics with non-suppressed viral loads
Key intervention effects: Increased viral suppression
Location: Kansas City, KS (university-based outpatient infectious disease clinic)
Study years: 2018
Structural components: Access, Social Determinants of Health
EHE pillar: Treat
Poplin, V., Katz, J., Herrman, M., Robertson, K., Chen, G., Clough, L. A. & Newman, J. R. (2023). Effectiveness of a “Suppression Bundle” to improve HIV virologic suppression in an outpatient infectious disease clinic: A pilot implementation study. AIDS Care, 35(7), 1064-1068. doi: 10.1080/09540121.2022.2040720
Electronic Health Record (EHR) Alert for HIV Screening uses an electronic health record algorithm that identifies patients in an urban emergency department (ED) who meet specific criteria for HIV screening, as defined by the United States Preventive Services Tasks Force (USPSTF). Triage nurses receive the alert, obtain consent from the patient, and place an order for the screening.
Intended population: Persons of unknown HIV status recommended for routine HIV screening
Key intervention effects: Increased HIV screening
Location: St. Louis, MO (emergency departments)
Study years: 2019
Structural components: Access, Policy/Procedure
EHE pillar: Diagnose
Bitter, C. C., Parmentier, M., Subramaniam, D. S., Byrne, L., & Buchanan, P. (2022). An electronic health record alert increases human immunodeficiency virus screening and case identification in a high-risk emergency department population. International Journal of STD & AIDS, 33(7), 722-725. doi: 10.1177/09564624221096001.
Individualized Provider Feedback on HIV/HCV Testing employs a physician champion who uses text messages and emails to provide individualized feedback with peer comparisons to all ED providers about their performance for HIV and Hepatitis C Virus (HCV) testing.
Intended population: Emergency department (ED) patients
Key intervention effects: Increased HIV testing
Location: New York City, NY (two hospital emergency departments)
Study years: 2018 – 2019
Structural components: Access, Capacity Building
EHE pillar: Diagnose
Zucker, J., Purpura, L., Sani, F., Huan, S., Schluger, A., Ruperto, K., Slowkowski, J., Olender, S., Scherer, M., Castor, D., & Gordon, P. (2022). Individualized provider feedback increased HIV and HCV screening and identification in a New York City emergency department. AIDS Patient Care and STDs, 36(3):106-114 doi: 10.1089/apc.2021.0225
KC Life 360 is implemented by the Kansas City Health Department in partnership with community agencies to increase employment and housing services for PWH using a two-pronged approach that provides direct client navigation and system-level service coordination.
Intended population: Persons with HIV (PWH) who are unstably housed, experiencing homelessness, experiencing domestic violence, unemployed or under-employed; PWH who are virally unsuppressed, newly diagnosed with HIV, or are out of care
Key intervention effects: Increased viral suppression
Location: Kansas City, KS (community agencies)
Study years: 2018 – 2020
Structural components: Capacity Building, Physical Structure, Social Determinants of Health
EHE pillar: Treat


Lightner, J. S., Barnhart, T., Shank, J., Adams, D., Valleroy, E., Chesnut, S., & Rajabiun, S. (2022). Outcomes of the KC life 360 intervention: Improving employment and housing for persons living with HIV. PLoS ONE, 17(9), e0274923. doi: 10.1371/journal.pone.0274923