Prevention Research Synthesis
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Prevention Research Synthesis (PRS) HIV Compendium of Best Practices

Interventions: 250
 
 Starting January 2024, the linked intervention PDFs below are final and cannot be updated. New interventions will be summarized with key variables in the search results, but no new PDFs will be added to the Compendium search.
2GETHER

2GETHER teaches couples to use relationship skills to improve relational functioning and sexual health via a telehealth delivery model. The intervention includes the following three videoconferencing group sessions led by two trained facilitators aimed at building skills. Before each session, participants view self-paced video modules that address communication skills, coping with stress, relationship satisfaction, and HIV transmission.

Intended population: Young male couples

Key intervention effects: Decreased condomless anal sex, Decreased number of condomless anal sex partners, Decreased sexually transmitted infections (STIs)

Location: None reported

Study Years: 2018 – 2020

Structural components: None reported

EHE pillar: None



Newcomb, M. E., Swann, G., Macapagal, K., Sarno, E. L., Whitton, S. W., & Mustanski, B. (2023). Biomedical and behavioral outcomes of 2GETHER: A randomized controlled trial of a telehealth HIV prevention program for young male couples. Journal of Consulting and Clinical Psychology, 91(9), 505-520. doi: 10.1037/ccp0000823

Intervention materials or documentation: None reported. Contact author.
Contact email: newcomb@northwestern.edu
E-VOLUTION

E-VOLUTION is a mobile health (mHealth) intervention with a human support element. The intervention aims to improve assistance overcoming barriers to improve health outcomes with automated two-way messaging and live text messages between medical case managers and participants.

Intended population: Youth and young adults with HIV

Key intervention effects: Improved retention in HIV care, Improved HIV viral suppression

Location: St. Louis, MO (HIV clinic sites at Washington University School of Medicine)

Study years: 2017 – 2019

Structural components: None reported

EHE pillar: Treat



Gerke, D. R., Glotfelty, J., Slovacek, S., Freshman, M., Schlueter, J., & Plax, K. (2023). More than just reminders: Using text messaging to improve HIV care outcomes among youth and young adults living with HIV. AIDS and Behavior, 27(9), 2988–2996. doi.org/10.1007/s10461-023-04022-2

Intervention materials or documentation: None reported. Contact author.
Extension for Community Health Care Outcomes Model PrEP Curriculum (Project ECHO)

Extension for Community Health Care Outcomes Model PrEP Curriculum (Project ECHO) is an intervention that provides a virtual program to PrEP prescribers in primary and women’s healthcare clinics. The intervention is delivered to providers in sessions using clinical integration models built on existing STI management workflows aimed at increasing the numbers of PrEP prescribers and the volume of PrEP prescriptions.

Intended population: Clinic providers

Key intervention effects: Increase in providers prescribing PrEP; Increase in PrEP use

Location: New York, New York (primary care and women’s health clinics)

Study years: 2018 – 2021

Structural components: Access, Capacity Building, Physical Structure, Policy/Procedure, Social Determinants of Health

EHE pillars: Prevent




Casey, E., Kaplan-Lewis, E., Gala, K., & Lakew, R. (2023). Successful integration of HIV PrEP in primary care and women's health clinical practice: A model for implementation. Viruses, 15, 1365. doi.org/10.3390/v15061365

HIV PrEP Services for Urban Women

HIV PrEP Services for Urban Women is a multicomponent, educational HIV PrEP intervention that promotes universal PrEP services for women attending sexual and reproductive health centers.

Intended population: Healthcare providers in an urban sexual health clinic

Key intervention effects: Increased PrEP prescription/initiation for female clinic patients, Increased PrEP persistence for female clinic patients

Location: Washington, DC (sexual health clinic)

Study years: 2018 – 2019

Structural components: Access, Capacity Building, Policy/Procedure

EHE pillar: Prevent




Scott, R. K., Deyarmond, M., Marwitz, S., Huang, J. C., Moriarty, P., Visconti, A. J., Beverley, J., Elion, R., Coleman, M., & Hull, S. J. (2023). Implementation of an educational intervention to improve HIV pre-exposure prophylaxis services for women in an urban sexual health clinic. AIDS Patient Care and STDs, 37(9), 447-457. doi: 10.1089/apc.2023.0107

Intervention materials or documentation: None reported. Contact author.

RISE uses a trained peer counselor to conduct motivational interviewing (MI) with Black or African American PWH to address self-identified barriers to taking ART. The peer counselor also links PWH to services for unmet basic needs and encourages engagement with sources of resilience in Black or African American communities.

Intended population: Black or African American persons with HIV (PWH) on antiretroviral therapy (ART) but not yet virally suppressed and/or non-adherent to ART

Key intervention effects: Improved ART adherence

Location: Los Angeles, CA (community-based HIV services organization)

Study years: 2018 – 2021

Structural components: Social Determinants of Health

EHE pillar: Treat




Bogart, L. M., Mutchler, M. G., Goggin, K., Ghosh-Dastidar, M., Klein, D. J., Saya, U., Linnemayr, S., Lawrence, S. J., Tyagi, K., Thomas, D., Gizaw, M., Bailey, J., & Wagner, G. J. (2023). Randomized controlled trial of Rise, a community-based culturally congruent counseling intervention to support antiretroviral therapy adherence among Black/African American adults living with HIV. AIDS and Behavior, 27(5), 1573-1586. doi: 10.1007/s10461-022-03921-0

Intervention materials or documentation: None reported. Contact author.
Contact email: lbogart@rand.org
SMART Sex Ed

SMART Sex Ed is the first component of SMART, a stepped care package of eHealth interventions that addresses the sexual and HIV prevention needs of AMSM. SMART Sex Ed contains four modules that participants navigate in any order they choose. SMART Sex Ed is delivered in English or Spanish depending on participant preference.

Intended population: English and Spanish speaking adolescent men who have sex with men (AMSM), who are 13-18 years old and do not have HIV

Key intervention effects: Increased PrEP use

Location: United States and territories (online URL)

Study years: 2018 – 2020

Structural components: None reported

EHE pillar: Prevent



Mustanski, B., Saber, R., Macapagal, K., Matson, M., Laber, E., Rodriguez-Diaz, C., Moran, K. O., Carrion, A., Moskowitz, D. A., & Newcomb, M. E. (2023). Effectiveness of the SMART Sex Ed program among 13-18 year old English and Spanish speaking adolescent men who have sex with men. AIDS and Behavior, 27(2), 733-744. doi: 10.1007/s10461-022-03806-2

Intervention materials or documentation: For additional information contact Brian Mustanski.
Contact email: brian@northwestern.edu
Suppression Bundle

Suppression Bundle consists of three to five evidence-informed bundled strategies tailored to individual patients that aim to improve HIV viral suppression in persons with HIV at an outpatient infectious disease clinic setting. The Suppression Bundle addresses food insecurity, transportation, substance use, mental health, and HIV medication adherence.

Intended population: Patients at HIV clinics with non-suppressed viral loads

Key intervention effects: Increased viral suppression

Location: Kansas City, KS (university-based outpatient infectious disease clinic)

Study years: 2018

Structural components: Access, Social Determinants of Health

EHE pillar: Treat




Poplin, V., Katz, J., Herrman, M., Robertson, K., Chen, G., Clough, L. A. & Newman, J. R. (2023). Effectiveness of a “Suppression Bundle” to improve HIV virologic suppression in an outpatient infectious disease clinic: A pilot implementation study. AIDS Care, 35(7), 1064-1068. doi: 10.1080/09540121.2022.2040720

Intervention materials or documentation: None reported. Contact author.
Contact email: jnewman@kumc.edu
Electronic Health Record (EHR) Alert for HIV Screening

Electronic Health Record (EHR) Alert for HIV Screening uses an electronic health record algorithm that identifies patients in an urban emergency department (ED) who meet specific criteria for HIV screening, as defined by the United States Preventive Services Tasks Force (USPSTF). Triage nurses receive the alert, obtain consent from the patient, and place an order for the screening.

Intended population: Persons of unknown HIV status recommended for routine HIV screening

Key intervention effects: Increased HIV screening

Location: St. Louis, MO (emergency departments)

Study years: 2019

Structural components: Access, Policy/Procedure

EHE pillar: Diagnose



Bitter, C. C., Parmentier, M., Subramaniam, D. S., Byrne, L., & Buchanan, P. (2022). An electronic health record alert increases human immunodeficiency virus screening and case identification in a high-risk emergency department population. International Journal of STD & AIDS, 33(7), 722-725. doi: 10.1177/09564624221096001.

Intervention materials or documentation: None reported. Contact author.
Individualized Provider Feedback for HIV/HCV Testing

Individualized Provider Feedback on HIV/HCV Testing employs a physician champion who uses text messages and emails to provide individualized feedback with peer comparisons to all ED providers about their performance for HIV and Hepatitis C Virus (HCV) testing.

Intended population: Emergency department (ED) patients

Key intervention effects: Increased HIV testing

Location: New York City, NY (two hospital emergency departments)

Study years: 2018 – 2019

Structural components: Access, Capacity Building

EHE pillar: Diagnose



Zucker, J., Purpura, L., Sani, F., Huan, S., Schluger, A., Ruperto, K., Slowkowski, J., Olender, S., Scherer, M., Castor, D., & Gordon, P. (2022). Individualized provider feedback increased HIV and HCV screening and identification in a New York City emergency department. AIDS Patient Care and STDs, 36(3):106-114 doi: 10.1089/apc.2021.0225 

Intervention materials or documentation: None reported. Contact author.
Contact email: jz2700@cumc.columbia.edu
KC Life 360

KC Life 360 is implemented by the Kansas City Health Department in partnership with community agencies to increase employment and housing services for PWH using a two-pronged approach that provides direct client navigation and system-level service coordination.

Intended population: Persons with HIV (PWH) who are unstably housed, experiencing homelessness, experiencing domestic violence, unemployed or under-employed; PWH who are virally unsuppressed, newly diagnosed with HIV, or are out of care

Key intervention effects: Increased viral suppression

Location: Kansas City, KS (community agencies)

Study years: 2018 – 2020

Structural components: Capacity Building, Physical Structure, Social Determinants of Health

EHE pillar: Treat




Lightner, J. S., Barnhart, T., Shank, J., Adams, D., Valleroy, E., Chesnut, S., & Rajabiun, S. (2022). Outcomes of the KC life 360 intervention: Improving employment and housing for persons living with HIV. PLoS ONE, 17(9), e0274923. doi: 10.1371/journal.pone.0274923

Intervention materials or documentation: None reported. Contact author.
Contact email: lightnerj@umkc.edu