Co-occurrence of medical and psychiatric illness is very persistent and prevalent in World Trade Center (WTC) responders following the attacks of 9/11, impairing their daily functioning and treatment outcomes. For the first time, the proposed study will identify modifiable personality-informed risk factors, resilience characteristics, and mechanisms for maintenance of comorbid conditions, as well as propose, and test, using a proof-of-concept randomized control trial, a system of personality-informed interventions to improve care of vulnerable individuals. This study will inform planning of WTC-Health Program services and patient care, and will advance science by helping to illuminate the etiology of complex comorbidities.
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