Exploring Mechanisms of Obstructive Sleep Apnea (OSA) in WTC Responders

Project Number
U01 OH011481-01 A1
Icahn School of Medicine at Mount Sinai
Fiscal Year Awarded
Project Duration
3 years


There is a high prevalence of obstructive sleep apnea (OSA) in the WTC responder population with an increased risk for OSA in subjects with chronic rhinosinusitis. This study will examine the impact of upper airway sensory impairment from chronic rhinosinusitis as a potential mechanism for development of OSA in WTC responders. The study will also examine the contribution of other pathophysiologic mechanisms (impaired upper airway muscle responsiveness, low arousal threshold and loop gain) in the development of OSA that may be used to target therapeutic interventions in the future in this population.


Jag Sunderram, MD


No publications available at this time.

Image of Indu  Ayappa, PhD
Principal Investigator: Indu Ayappa, PhD
Icahn School of Medicine at Mount Sinai