We seek to understand the bases for the still-increasing incidence of cardiovascular (CV)/neurodegenerative anomalies of 9/11 First Responders (FR). These studies will be performed in a rat model exposed to WTC dusts obtained within 72 hr after the buildings collapsed, using exposures that mimic exposures and dust levels faced by FR. These results will: clarify whether exposure to WTC dust exacerbates CV/neurologic phenotypes (effects that have led to changes in CV and brain health of exposed FR); ascertain if the dusts induce an Alzheimer Disease/PTSD phenotype in exposed hosts; obtain biochemical/molecular clues to the CV/neurologic problems of exposed FR.
Co-PI: Mitchell Cohen (New York University School of Medicine)
No publications available at this time.