Common sleep disorders like obstructive sleep apnea (OSA) may represent risk factors for cognitive decline. We have found a very high prevalence of OSA in the World Trade Center responder population, and the present work will evaluate the impact of OSA on early markers of Alzheimer 's Disease using plasma biomarkers, PET/MR and cognition using a visual-spatial memory test. This study has the potential to identify the mechanisms by which sleep disruption contributes to Alzheimer's Disease neurodegeneration and guide therapeutic interventions in the future in the aging WTC responder population.
Study Design: Prospective longitudinal cohort study
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