Role of Sleep Apnea in Cognition and Alzheimer’s Disease Biomarkers in WTC Responders

Project Number
1 U01 OH011852-01 A1
Icahn School of Medicine at Mount Sinai
Fiscal Year Awarded
Project Duration
5 year


Common sleep disorders like obstructive sleep apnea (OSA) may represent risk factors for cognitive decline. We have found a very high prevalence of OSA in the World Trade Center responder population, and the present work will evaluate the impact of OSA on early markers of Alzheimer 's Disease using plasma biomarkers, PET/MR and cognition using a visual-spatial memory test. This study has the potential to identify the mechanisms by which sleep disruption contributes to Alzheimer's Disease neurodegeneration and guide therapeutic interventions in the future in the aging WTC responder population.


Study Design: Prospective longitudinal cohort study


No publications available at this time.

Image of Indu  Ayappa, PhD
Principal Investigator: Indu Ayappa, PhD
Icahn School of Medicine at Mount Sinai