World Trade Center (WTC) site destruction caused an intense particulate matter (PM) exposure. Since PM is responsible for a high percentage of cardiorespiratory disease/death we propose to investigate the development of WTC-PM induced cardiorespiratory and vascular dysfunction (WTC-CaRVD) in the FDNY cohort. Our proposal will identify biologically plausible therapeutic targets of oxidative stress and clinical phenotypes of WTC-CaRVD; which falls squarely within the purview of the James Zadroga 9/11 Health & Compensation Act.
Study Design: Case-Control
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