World Trade Center (WTC) exposed Fire Department of New York (FDNY) rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett’s Esophagus (BE) and subsequent esophageal cancer. There is diminished health-related quality of life and productivity associated with aerodigestive diseases such as GERD and BE. Our research will leverage the longitudinally phenotyped WTC exposed cohort, identify/validate novel biomarkers of WTC-aerodigestive disease, develop novel, noninvasive disease phenotyping to promote early diagnosis of premalignant disease, and identify potential targeted therapeutics; goals that are in line with the James Zadroga 9/11 Health & Compensation Act.
Study Design: Case-Control
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