Aerodigestive Disease in the World Trade Center Exposed FDNY Cohort: Validation of Biomarkers and Defining Risk to Tailor Therapy

Project Number
1 U01 OH012069-01 A1
New York City Department of Health and Mental Hygiene
Fiscal Year Awarded
Project Duration
3 year


World Trade Center (WTC) exposed Fire Department of New York (FDNY) rescue and recovery workers developed gastroesophageal reflux disease (GERD), a risk factor for Barrett’s Esophagus (BE) and subsequent esophageal cancer. There is diminished health-related quality of life and productivity associated with aerodigestive diseases such as GERD and BE. Our research will leverage the longitudinally phenotyped WTC exposed cohort, identify/validate novel biomarkers of WTC-aerodigestive disease, develop novel, noninvasive disease phenotyping to promote early diagnosis of premalignant disease, and identify potential targeted therapeutics; goals that are in line with the James Zadroga 9/11 Health & Compensation Act.

Study Design: Case-Control


No publications available at this time.

Image of Mark  Farfel, ScD
Principal Investigator: Mark Farfel, ScD
New York City Department of Health and Mental Hygiene