World Trade Center (WTC) responders are showing signs of mild cognitive impairment (MCI), a symptom consistent with neurodegenerative diseases earlier than general population. For the first time, we will compare the monocyte transcriptome and plasma markers of cerebral neuropathology of Stony Brook WTC Health Program responders within a longitudinal study design to identify molecular mechanisms underlying monocyte dynamics and the biological processes involved in the progression of MCI to dementia. This knowledge will help identify novel blood-based biomarkers for early detection of Alzheimer’s disease, and inform development of novel treatments.
Study Design: Longitudinal
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