Our proposal aims to detect mutations associated with early signs of clonal hematopoiesis and blood cancers in samples from firefighters who were exposed to the World Trade Center (WTC) dust after the 9/11 terrorist attack. To test how WTC exposure results in increased mutations, we will also study the effects of exposure to WTC dust in animal models. Early detection of these cases would enable clinical evaluation and potentially disease altering therapeutic interventions for firefighters.
Study Design: Case series evaluating incidence of mutations on banked samples
No publications available at this time.
