The project aims at correlating a detailed assessment of exposure of World Trade Center (WTC) responders enrolled at program at Stony Brook with alterations the mechanism of regulation of DNA called methylation, which may be relevant to cancer risk. The project is expected to contribute to understanding of the possible role of DNA methylation as marker of exposure to carcinogenic exposure among WTC responders. If the results confirm a correlation between WTC exposures, assessed through a high-quality methodology, and altered DNA methylation, they might lead to the development of strategies to identify WTC responders at increased risk of cancer and other chronic diseases.
Kuan, PF, Mi Z, Georgopoulos P, et al. 2018. Enhanced exposure assessment and genome-wide DNA methylation in World Trade Center disaster responders. Eur J Cancer Prev. [epub ahad of print] July 11, 2018.