Enhanced Assessment of WTC Exposure and Global DNA Methylation

Project Number
Icahn School of Medicine at Mount Sinai
Fiscal Year Awarded
Project Duration
1 year


The project aims at correlating a detailed assessment of exposure of World Trade Center (WTC) responders enrolled at program at Stony Brook with alterations the mechanism of regulation of DNA called methylation, which may be relevant to cancer risk. The project is expected to contribute to understanding of the possible role of DNA methylation as marker of exposure to carcinogenic exposure among WTC responders. If the results confirm a correlation between WTC exposures, assessed through a high-quality methodology, and altered DNA methylation, they might lead to the development of strategies to identify WTC responders at increased risk of cancer and other chronic diseases.


Image of Paolo  Boffetta, MD
Principal Investigator: Paolo Boffetta, MD
Icahn School of Medicine at Mount Sinai