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  Congo   CONV

Arbovirus

No

4

Level assigned to prototype or wild-type virus. A lower level may be recommended for laboratory strains or geographic variants of the virus with well-defined reduced virulence characteristics, as mentioned in the text.
Other Information
 

CHF-CON
Section V - Antigenic Relationship and Lack of Relationship to Other Viruses
 
It was screened by CF at 1/5 and 1/40 against hyperimmune antisera to the following African arboviruses without finding any significant relationship:
 


Bunyamwera Ingwavuma Lebombo
Germiston Simbu Lumbo
Ilesha African horsesickness Mossuril
Olifantsvlei Bluetongue Orungo
Shokwe Chenuda Nairobi sheep disease
Bwamba Dakar Nyamanini
Pongola Lagos bat Nyando
Quaranfil Tanga Tete
Thogoto Wad Medani Witwatersrand
It was also negative with hyperimmune Herpes simmplex antiserum.
Hyperimmune antiserum (V 3011) has been screened at 1/10 by HI with negative results against the following antigens:
 


Group A chikungunya, Semliki forest virus, Sindbis
Group B yellow fever, West Nile, Zika, Banzi
Bunyamwera (Aedes '43)
Casals [10] has shown 3 strains of Congo virus (Congo 3010, Uganda K2/61, Pakistan JD 206) to be atnigenically indistinguishable from each other and from the Drosdov strain of Crimean hemorrhagic fever (CHF) by CF tests. NT and agar gel precipitin tests confirm this relationship.
Hazara virus found to be related to but distinct from Congo virus by NT [20] and C (see HAZ registration). Also related by HI [19] .
A low-titered relationship by CF, fluorscent antibody and indirect HA demonstrated between CON and NSD viruses [23] , [24] . SIRACA has decided that these relations are no greater than those used to establish the Bunyamwera Supergroup. The CON and NSD antigenic groups should be kept as two distinct serogroups.
Following the above observations, intergroup relationships were demonstrated for members of the above two serogroups as well as for members of the DGK, HUG, QYB and SAK serogroups [30] .
 
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